FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\upd1YC43
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General Information
Symbol
Dmel\upd1YC43
Species
D. melanogaster
Name
FlyBase ID
FBal0013296
Feature type
allele
Associated gene
Dmel\upd1
Associated Insertion(s)
Carried in Construct
Also Known As
updYC43
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Eberl et al., 1992)
Progenitor genotype
Cytology
Description

A 2bp insertion that causes a frameshift mutation after amino acid 144 of the upd1 protein.

(Hombria et al., 2005)

2bp insertion at codon 143.

(Sefton et al., 2000)

2bp insertion causing a frameshift mutation in the open reading frame.

(Harrison et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
insertion
X:18,307,094..18,307,095 [-]
Comment:

A 2bp insertion (AG) causing a frameshift mutation in the upd1 open reading frame.

Inserted_sequence:

AG

(Sefton et al., 2000, Harrison et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      upd1YC43 mutants show premature differentiation to P1+ plasmatocytes.

      (Sinha et al., 2013)

      upd1YC43 embryos show defects in the following segments (penetrance levels are shown in brackets): T2 (56%), A4 (52%), A5 (78%), A6 (7%), A7 (4%) and A8 (26%).

      (Hombria et al., 2005)

      The proventriculus development is normal in early stages of proventriculus development in mutants. However in the keyhole stage, the anterior boundary cells fail to move inward into the endodermal keyhole domain and arrest anterior to the proventricular endoderm until late stages of embryonic development. Furthermore, the endodermal cell layer of the keyhole is disorganised and the proventriculus is collapsed.

      (Josten et al., 2004)

      The enlarged eye phenotype seen in flies carrying one copy of upd1GMR.PB is not modified if the flies are also carrying upd1YC43.

      (Bach et al., 2003)

      Fails to complement the wing phenotype of Df(1)oso; Df(1)oso/upd1YC43 flies are viable with outstretched wings.

      (Harrison et al., 1998)

      Defect in the fourth and fifth abdominal denticle belt. This does not produce embryonic lethality as mutant larvae, pupae and sometimes adult can develop lacking the abdominal region. T2, T3 and A8 are sometimes deleted, the head is usually involuted but most head structures are present. Germline clone analysis of os alleles of the upd complementation group indicate they are not required for germline viabilty and do not have a maternal effect.

      (Eberl et al., 1992)

      Interacts with RpII140wimp maternal effect.

      (Parkhurst and Ish-Horowicz, 1991)

      embryonic lethal Mutants show variable larval cuticular phenotype with defects predominantly in the mesothorax and the fifth abdominal segment (Nusslein-Volhard et al., 1984; Gergen and Wieschaus, 1986); also some head defects and fourth, sixth, seventh and eighth abdominal segment defects. Heterozygotes show 88-93% viability (Wieschaus and Noell, 1986). T2, A5, A8 denticle belts deleted; A6 and A7 denticle belts fused; abnormal posterior spiracles

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      upd1YC43/os[+] is an enhancer of egg chamber phenotype of hop27/hop25

      (McGregor et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      75% of hop25 upd1YC43/hop27 egg chambers are fused.

      (McGregor et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (9)
      References (15)