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General Information
Symbol
Dmel\upd1YC43
Species
D. melanogaster
Name
FlyBase ID
FBal0013296
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
updYC43
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

A 2bp insertion (AG) causing a frameshift mutation in the upd1 open reading frame.

Inserted_sequence:

AG

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A 2bp insertion that causes a frameshift mutation after amino acid 144 of the upd1 protein.

2bp insertion at codon 143.

2bp insertion causing a frameshift mutation in the open reading frame.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

upd1YC43 mutants show premature differentiation to P1+ plasmatocytes.

upd1YC43 embryos show defects in the following segments (penetrance levels are shown in brackets): T2 (56%), A4 (52%), A5 (78%), A6 (7%), A7 (4%) and A8 (26%).

The proventriculus development is normal in early stages of proventriculus development in mutants. However in the keyhole stage, the anterior boundary cells fail to move inward into the endodermal keyhole domain and arrest anterior to the proventricular endoderm until late stages of embryonic development. Furthermore, the endodermal cell layer of the keyhole is disorganised and the proventriculus is collapsed.

The enlarged eye phenotype seen in flies carrying one copy of upd1GMR.PB is not modified if the flies are also carrying upd1YC43.

Fails to complement the wing phenotype of Df(1)oso; Df(1)oso/upd1YC43 flies are viable with outstretched wings.

Defect in the fourth and fifth abdominal denticle belt. This does not produce embryonic lethality as mutant larvae, pupae and sometimes adult can develop lacking the abdominal region. T2, T3 and A8 are sometimes deleted, the head is usually involuted but most head structures are present. Germline clone analysis of os alleles of the upd complementation group indicate they are not required for germline viabilty and do not have a maternal effect.

Interacts with RpII140wimp maternal effect.

embryonic lethal Mutants show variable larval cuticular phenotype with defects predominantly in the mesothorax and the fifth abdominal segment (Nusslein-Volhard et al., 1984; Gergen and Wieschaus, 1986); also some head defects and fourth, sixth, seventh and eighth abdominal segment defects. Heterozygotes show 88-93% viability (Wieschaus and Noell, 1986). T2, A5, A8 denticle belts deleted; A6 and A7 denticle belts fused; abnormal posterior spiracles

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

upd1YC43/os[+] is an enhancer of egg chamber phenotype of hop27/hop25

Additional Comments
Genetic Interactions
Statement
Reference

75% of hop25 upd1YC43/hop27 egg chambers are fused.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (9)
References (15)