FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pic2
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General Information
Symbol
Dmel\pic2
Species
D. melanogaster
Name
FlyBase ID
FBal0013795
Feature type
allele
Associated gene
Dmel\pic
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Hu et al., 2008)
Mutagen
X ray
(Hilliker et al., 1981)
Progenitor genotype
Cytology
Description

Amino acid replacement: G21D.

(Hu et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pic2/picPL12c animals develop into viable adults, but these animals show a significant developmental delay and eclose on average 2 to 4 days later than control siblings at 25[o]C and 18[o]C respectively. The flies have cuticle defects including missing bristles and small bristles that resemble those of Minute mutants.

      (Hu et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      picPL12c/pic2 has partially lethal - majority die phenotype, suppressible by gig[+]/gig192

      (Hu et al., 2008)

      picPL12c/pic2 has abnormal developmental rate phenotype, suppressible by gig[+]/gig192

      (Hu et al., 2008)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      picPL12c/pic2 has macrochaeta phenotype, non-suppressible by gig[+]/gig192

      (Hu et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for gig192 substantially suppresses the late eclosion phenotype and the semi-lethality of pic2/picPL12c animals, but the bristle defects caused by pic2/picPL12c are not significantly suppressed by gig192/+.

      (Hu et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      May show interallelic complementation for viability, but survivors are pic in phenotype (Hilliker, Clark and Chovnick, 1980; Hilliker, Clark, Gelbart and Chovnick, 1981; Clark and Chovnick, 1986).

      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Schalet.

      Induced on: kar2.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Ddb1pic2
      (Hu et al., 2008)
      l(3)pic2l
      (Hilliker et al., 1981)
      pic2
      (Lee et al., 2010, Hu et al., 2008)
      pic2l
      Name Synonyms
      piccolo-2 lethal
      Secondary FlyBase IDs
        References (4)