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General Information
Symbol
Dmel\pll7
Species
D. melanogaster
Name
FlyBase ID
FBal0013861
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
pll385
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

A27251753T

Amino acid change:

I362F | pll-PA; I362F | pll-PB

Reported amino acid change:

I362F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: I362F.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

pll7/pll2 and pll7/pll25 larvae show show mistargeting of the R2-R5 photoreceptor axons in the developing visual system; thickened bundles of axons along the entire length of the lamina are observed to penetrate into the medulla, while the lamina is not smooth and is somewhat irregular.

The ability of pll7/pll2 larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.

Homozygous and pll7/pll25 larvae have significantly higher levels of muscle defects than wild-type larvae.

Embryos from mutant mothers develop only dorsal epidermis.

Homozygotes and heterozygotes with Df(3R)R38.3 have a completely dorsalised phenotype and a stronger dorsalised phenotype when heterozygous with pll16.

Embryos derived from homozygous females are dorsalised.

dppHin embryos derived from pll7 mothers have a dorsalizing phenotype: dorsal setae covering the entire body, rudimentary posterior spiracles lacking Filzkorper and numerous ventral like setae. Individuals have an elongated and convoluted appearance.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement
Reference

pll7 has embryo | ventral phenotype, non-suppressible by tor::tubt4021t

Enhancer of
Additional Comments
Genetic Interactions
Statement
Reference

The variable dorsalized embryonic phenotype of wekEX14 mutants is enhanced by pll7. While 51% of wekEX14 embryos show an extreme dorsalized phenotype, this penetrance is increased to 92% in wekEX14; pll7/+ embryos.

Double mutant combinations with eaD1 are strongly dorsalized.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (23)