FlyBase Allele Report: Dmel\sc[4]

General Information

Symbol

Dmel\sc⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0015193

Feature type

allele

Associated gene

Dmel\sc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

Progenitor genotype

Caused by aberration

In(1)sc⁴

Cytology

Description

Breakpoint is 7 kb 3' of the sc transcribed region.

(Cubas et al., 1991)

kb 25.8 to 24.0; (Carramolino, Ruiz-Gomez, Guerrero, Campuzano, and Modolell (1982) and Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat and Modolell (1985). 0 defined as the more distal EcoRI site within the sc^S2 molecular deficiency; positive values extend to the left.)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Malva et al., 1985)

visible

(Golovnin et al., 1999)

visible | recessive

(Gomez-Skarmeta et al., 1995, Held, 1990)

Phenotype Manifest In

Detailed Description

Statement

Reference

More than 90% of flies lack the anterior orbital, anterior notopleural, humeral, postvertical, ocellar, presutural, anterior postalar, anterior supraalar, scutellar and posterior postalar bristles. More than 10% of flies lack the posterior supraalar bristles.

(Golovnin et al., 1999)

Anterior notopleural macrochaetae are removed.

(Gomez-Skarmeta et al., 1995)

Levels of sc protein are much lower than wild type, accumulation in clusters is still detectable. The PNP, APA and PSA notum macrochaetae are present.

(Cubas et al., 1991)

The number of bractless bristles on the basitarsi of the second legs is reduced. A number of bristles with split shafts are seen.

(Held, 1990)

The sc4d campaniform sensilla are missing in 90-100% of hemizygous flies.

(Leyns et al., 1989)

Lacks most of the notum macrochaetae. sc RNA was much less abundant than wild type.

(Romani et al., 1989)

The presence of an X-chromosome carrying the In(1)sc⁴ inversion in abo mothers produces an enhancement of the abo maternal effect. A zygotic effect is also seen resulting in the lethality of the progeny homozygous for abo and In(1)sc⁴. Authors imply that effect is due to the proximal breakpoint in In(1)sc⁴ affecting the function of the ABO-X locus.

(Malva et al., 1985)

Extreme scute. Bristles of head, except anterior verticals, absent. Only posterior notopleurals and alars remain on sides of mesothorax; abdominals, ventrals, coxals, and scutellars also missing. Slight variegation for Hw. RK1A.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

sc⁴ has phenotype, enhanceable by emc[+]/emc^D

(Mari-Beffa et al., 1991)

Suppressed by