FlyBase Allele Report: Dmel\scw[5]

General Information

Symbol

Dmel\scw⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0015345

Feature type

allele

Associated gene

Dmel\scw

Associated Insertion(s)

Carried in Construct

Also Known As

scw^s12

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Raftery et al., 1995, Arora et al., 1994, Arora and Nusslein-Volhard, 1992)

loss of function allele

(Biehs et al., 1996, Ray et al., 1991)

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mis-sense mutation.

(Fritsch et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous embryos form some residual visceral mesoderm, although heart formation is disrupted.

(Yin and Frasch, 1998)

Heterozygotes with Df(2L)OD16 exhibit loss of head structures and filzkorper. Denticle belt organisation is disrupted. No effect on dpp^hr4 lethality, the number of amnioserosa cells is comparable to wild type.

(Raftery et al., 1995)

Anterior dorsal structures are missing, amnioserosa is missing, filzkorper significantly reduced and ventral denticle belts are expanded laterally. Injection of dpp^fl.cAa transcripts can suppress the mutant phenotype and restore the dorsal most pattern element, the amnioserosa.

(Arora et al., 1994)

Moderate ventralised phenotype. No amnioserosa, reduction of dorsal cuticle and increase in the width of the ventral setal belts in each segment. Leads to defective movements of the germ band. Dorsal cell fates are deleted and ventrolateral mitotic domains are expanded.

(Arora and Nusslein-Volhard, 1992)

Ventralized embryos: rings or patches of ventral denticles along dorsoventral axis. Disruption of germ band extension that leads to the invagination of posterior segments into the interior of the embryo.

(Ray et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

scw⁵ has lethal | recessive phenotype, non-enhanceable by lilli^unspecified

(Su et al., 2001)

Suppressed by

Statement

Reference

scw⁵/Df(2L)OD16 has lethal phenotype, suppressible by Dgri\scw^+tFa

(Fritsch et al., 2010)

NOT suppressed by

Statement

Reference

scw⁵/Df(2L)OD16 has lethal phenotype, non-suppressible by gbb^scw.PF

(Fritsch et al., 2010)

scw⁵/Df(2L)OD16 has lethal phenotype, non-suppressible by Gmor\scw^+tFa

(Fritsch et al., 2010)

scw⁵/Df(2L)OD16 has lethal phenotype, non-suppressible by Gmor\scw^gbb.PF

(Fritsch et al., 2010)

scw⁵/Df(2L)OD16 has lethal phenotype, non-suppressible by Gmor\scw^LD.gbb

(Fritsch et al., 2010)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Zzzz\scw^+tFa, Zzzz\scw^gbb.PF and Zzzz\scw^LD.gbb each fail to rescue the lethality of scw⁵/Df(2L)OD16 animals.

Dgri\scw^+tFa rescues the lethality of scw⁵/Df(2L)OD16 animals.

(Fritsch et al., 2010)

Complementation and Rescue Data

Rescued by

scw⁵/Df(2L)OD16 is rescued by scw^+t5.1

(Fritsch et al., 2010)

Partially rescued by

scw⁵/Df(2L)OD16 is partially rescued by scw^WT.Tag:FLAG

(Fritsch et al., 2012)

scw⁵/Df(2L)OD16 is partially rescued by scw^{R54G.Tag:FLAG}

(Fritsch et al., 2012)

scw⁵/Df(2L)OD16 is partially rescued by scw^{R276G.R277A.Tag:FLAG}

(Fritsch et al., 2012)

Not rescued by

scw⁵/Df(2L)OD16 is not rescued by scw^{R91H.Tag:FLAG}

(Fritsch et al., 2012)

scw⁵/Df(2L)OD16 is not rescued by scw^{R271G.Tag:FLAG}

(Fritsch et al., 2012)

scw⁵/Df(2L)OD16 is not rescued by scw^gbb.PF

(Fritsch et al., 2010)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

7306

w¹¹¹⁸; Adc^b-1 scw⁵ pr¹/CyO, P{sevRas1.V12}FK1

Kyoto

101414

CyO, Duox^Cy dpy^lv1 pr¹ cn² / Adc^b-1 scw⁵ pr¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

l(2)37Ff^S12

(Jones and McGinnis, 1993)

scw⁴

scw⁵¹²

(Biehs et al., 1996)

scw⁵

(Künnapuu et al., 2014, Weyers et al., 2011, Salzer et al., 2010)

scw^S12

(Tauscher et al., 2016, Fritsch et al., 2012, Fritsch et al., 2010, Bartoszewski et al., 2004, Su et al., 2001, Nguyen et al., 1998, Yin and Frasch, 1998, Harbecke and Lengyel, 1995, Raftery et al., 1995, Arora et al., 1994, Arora and Nusslein-Volhard, 1992, Tearle and Nusslein-Volhard, 1987)

scw^s12

(Wang and Ferguson, 2005, Hamaguchi et al., 2004, Srinivasan et al., 2002, Chang et al., 2001, Rusch and Levine, 1997, Ray et al., 1991)

Name Synonyms

Secondary FlyBase IDs

References (23)

Report Sections

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