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General Information
Symbol
Dmel\Serrev6-1
Species
D. melanogaster
Name
FlyBase ID
FBal0015432
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Serrev6.1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

denticle row 3 & abdominal 3 ventral denticle belt

denticle row 3 & abdominal 4 ventral denticle belt

denticle row 3 & abdominal 5 ventral denticle belt

denticle row 3 & abdominal 6 ventral denticle belt

denticle row 3 & abdominal 7 ventral denticle belt

denticle row 3 & abdominal 8 ventral denticle belt

denticle row 4 & abdominal 2 ventral denticle belt

denticle row 4 & abdominal 3 ventral denticle belt

denticle row 4 & abdominal 4 ventral denticle belt

denticle row 4 & abdominal 5 ventral denticle belt

denticle row 4 & abdominal 6 ventral denticle belt

denticle row 4 & abdominal 7 ventral denticle belt

denticle row 4 & abdominal 8 ventral denticle belt

Detailed Description
Statement
Reference

Mutants have unsegmented legs.

Homozygous larvae show complete fusion of denticle rows 3 and 4 in abdominal segments A2 to A8. The denticles in the fused row have no regular polarity and about half the larvae develop small denticles in this row.

Dominantly suppresses the ability of Src42ASu(phl)1-1 to suppress the lethality of phl1/Y flies.

Homozygous clones in the adult scutum have normal bristle structures. Homozygous clones induced in the sensory organ lineage have a similar phenotype to homozygous SerRX82 clones induced in the sensory organ lineage.

Heterozygotes with SerBd-3 appear phenotypically identical to SerBd-3 heterozygotes: loss of anterior wing margin material.

Homozygotes die at the late embryo/early larval stage and exhibit defects in head structures, particularly in the development of the mouth hooks.

Clones can cause extensive non-autonomous loss of wing tissue but only when the clone includes cells that abut the compartment boundary in the dorsal compartment. Dorsally or ventrally located clones that do not include the compartment boundary produce no distinct phenotype.

Homozygotes display a continuous and complex range of phenotypes, including nonretracted germ band, faintly stained denticles and dorsal hairs and cuticular holes. Examination of the nervous system also revealed a range of phenotypes including a disruption of the longitudinal and commissural axon tracts.

homozygous lethal

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Other
Phenotype Manifest In
Suppressed by
Statement
Reference
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

Serrev6-1/Ser[+] is a suppressor of phenotype of Src42ASu(Raf)1-1

Additional Comments
Genetic Interactions
Statement
Reference

Heterozygous Serrev6-1 enhances the wing nicking phenotype seen in mamN.Scer\UAS, Scer\GAL4C96. The wing bristle phenotype seen in SerScer\UAS.cGa, Scer\GAL4C96 flies is mildly suppressed by the addition of mamN.Scer\UAS.

Enhances the Dfd13/Dfd3 phenotype; reduces the survival of Dfd13/Dfd3 hypomorphs.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

fails to complement SerBd-3

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Fleming.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)