FlyBase Allele Report: Dmel\sina[4]

General Information

Symbol

Dmel\sina⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0015668

Feature type

allele

Associated gene

Dmel\sina

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lindsley and Zimm, 1992)

loss of function allele

(Kauffmann et al., 1996)

Mutagen

ethyl methanesulfonate

(Carthew and Rubin, 1990)

Progenitor genotype

Cytology

Description

Amino acid replacement: H184Y.

(Carthew et al., 1994)

Amino acid replacement: H184Y. Nucleotide substitution: C1452T.

(Carthew and Rubin, 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:16,856,967..16,856,967 [+]

Nucleotide change:

C16856967T

Reported nucleotide change:

C1452T

Amino acid change:

H184Y | sina-PA; H184Y | sina-PB; H184Y | sina-PC

Reported amino acid change:

H184Y

Comment:

Nucleotide coordinate of mutation determined from Figure 5B of FBrf0051381 and differs from the position listed in Table 1.

(Carthew and Rubin, 1990)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

photoreceptor cell R7

(Kauffmann et al., 1996)

Detailed Description

Statement

Reference

20% ommatidia have lost the R7 photoreceptor cell.

(Kauffmann et al., 1996)

80% of homozygotes are wild type for R7 cell formation, 90% of hemizygotes are missing R7 cells.

(Carthew et al., 1994)

Weak allele.

(Carthew and Rubin, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

sina⁴ is a non-enhancer of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

sina⁴ is a non-enhancer of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

NOT Suppressor of

Statement

Reference

sina⁴ is a non-suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

sina⁴ is a non-suppressor of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

sina⁴ has phenotype, enhanceable by SS3-6^s297

(Neufeld et al., 1998)

sina⁴ has phenotype, enhanceable by fry^s308

(Neufeld et al., 1998)

sina⁴ has phenotype, enhanceable by Sin3A^e64

(Neufeld et al., 1998)

sina⁴ has phenotype, enhanceable by ES1-1^e341

(Neufeld et al., 1998)

sina⁴ has phenotype, enhanceable by S^e220

(Neufeld et al., 1998)

sina⁴ has phenotype, enhanceable by pros¹⁰⁴¹⁹

(Kauffmann et al., 1996)

sina⁴ has phenotype, enhanceable by pros^JO1

(Kauffmann et al., 1996)

sina⁴ has phenotype, enhanceable by E(sina)1^D1

(Carthew et al., 1994)

sina⁴ has phenotype, enhanceable by E(sina)3^K1

(Carthew et al., 1994)

sina⁴ has phenotype, enhanceable by E(sina)46C^M1

(Carthew et al., 1994)

sina⁴ has phenotype, enhanceable by E(sina)4^K5

(Carthew et al., 1994)

sina⁴ has phenotype, enhanceable by E(sina)6^L3

(Carthew et al., 1994)

sina⁴ has phenotype, enhanceable by E(sina)6^M4

(Carthew et al., 1994)

sina⁴ has phenotype, enhanceable by gl^ES5

(Carthew et al., 1994)

sina⁴ has phenotype, enhanceable by pnut^H2

(Carthew et al., 1994)

sina⁴ has phenotype, enhanceable by rl^ES7

(Carthew et al., 1994)

sina⁴ has phenotype, enhanceable by Hsp83^H3

(Carthew et al., 1994)

sina⁴ has photoreceptor cell R7 phenotype, enhanceable by pnut¹

(Neufeld and Rubin, 1994)

Suppressed by

Statement

Reference

sina⁴ has phenotype, suppressible by ES3-1^e139

(Neufeld et al., 1998)

NOT Enhancer of

Statement

Reference

sina⁴ is a non-enhancer of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

sina⁴ is a non-enhancer of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

NOT Suppressor of

Statement

Reference

sina⁴ is a non-suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

sina⁴ is a non-suppressor of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Other

Statement

Reference

E(sina)4^K5, sina⁴ has secondary pigment cell phenotype

(Carthew et al., 1994)

Hsp83^H3, sina⁴ has secondary pigment cell phenotype

(Carthew et al., 1994)

E(sina)6^M4/E(sina)6^L3, sina⁴ has wing vein | ectopic phenotype

(Carthew et al., 1994)

E(sina)6^M4/E(sina)6^L3, sina⁴ has posterior crossvein phenotype

(Carthew et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

No interaction with P{sev-svp1} or P{sev-svp2} exists.

(Begemann et al., 1995)

Weak allele. Immunohistochemistry demonstrates that the mutation does not affect gene product abundance or localisation.

(Carthew et al., 1994)

Weak sina mutation.

(Kauffmann et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sina⁴

(Zheng and Carthew, 2008)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

Open Close