FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\snk4
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General Information
Symbol
Dmel\snk4
Species
D. melanogaster
Name
FlyBase ID
FBal0015912
Feature type
allele
Associated gene
Dmel\snk
Associated Insertion(s)
Carried in Construct
Also Known As
snkrm4
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lindsley and Zimm, 1992, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Point mutation in the catalytic site.

(Lemaitre et al., 1996)

Nucleotide substitution: G661A. Amino acid replacement: G222R. G222 falls in a highly conserved region of the catalytic chain which is thought to have an essential role in normal catalysis.

(Smith et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:13,040,901..13,040,901 [-]
Nucleotide change:

G13040901A

Reported nucleotide change:

G661A

Amino acid change:

G221R | snk-PA; G221R | snk-PB; G221R | snk-PC

Reported amino acid change:

G222R

(Smith et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Bacterially challenged snk2/snk4 mutants exhibit a wild type Drs response. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate.

      (Lemaitre et al., 1996)

      Cell intercalation in lateralized snk mutant embryos proceeds normally during germ band extension.

      (Irvine and Wieschaus, 1994)

      Strongly dorsalized.

      (Smith et al., 1994)

      Strong allele.

      (Tearle and Nusslein-Volhard, 1987)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos derived from snk4 Tl3/snk2 + females differentiate cuticles encircled by ventral denticles. Injection of these embryos with tkvQ253D.SP6 RNA restores dorsal structures in a dose-dependent manner. Injection of these embryos with saxQ263D.SP6 RNA has little or no effect; none of these embryos develop amnioserosa and only 2% differentiate dorsal hairs. Injection of these embryos with saxQ263D.SP6 and tkvwt.SP6 RNA does not promote the formation of any dorsal structures. Injection of these embryos with both tkvQ253D.SP6 and saxQ263D.SP6 RNA results in a striking increase in the percentage of embryos that differentiate dorsal tissue types compared to embryos injected with the same concentration of tkvQ253D.SP6 RNA alone. Injection of these embryos with both tkvQ253D.SP6 and saxwt.SP6 RNA does not increase the formation of dorsal structures compared to embryos injected with tkvQ253D.SP6 RNA alone. Injection of these embryos with both tkvQ253D.SP6 and tkvDN.SP6 RNA does not increase the formation of dorsal structures compared to embryos injected with tkvQ253D.SP6 RNA alone.

      (Neul and Ferguson, 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (11)