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General Information
Symbol
Dmel\spz3
Species
D. melanogaster
Name
FlyBase ID
FBal0016061
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
spz67
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

A27066114G

Reported nucleotide change:

A620G

Amino acid change:

Q263R | spz-PA; Q237R | spz-PB; Q190R | spz-PC; Q210R | spz-PD; Q164R | spz-PI; Q181R | spz-PJ; Q227R | spz-PK; Q207R | spz-PL

Reported amino acid change:

Q207R

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q207R.

Nucleotide substitution: A620G.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

VA1d olfactory receptor neuron axon targeting is normal in mutant flies.

Embryonic lethal when heterozygous with the MBT chromosome.

Affected embryos show preferential loss of ventral structures and the expansion of lateral and dorsal structures.

Embryos derived from spz2/spz3 females are weakly dorsalised at 18oC. The mesoderm and ventral furrow are reduced in size, and mesoderm only develops in the posterior part of the embryo.

temperature-sensitive Temperature-sensitive period of spz3 extends from oogenesis through fertilization until about the time of pole-cell formation

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

spz3/pll2, spz3/pll8 or spz3/pll1 does not result in neoplasms.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (10)