FlyBase Allele Report: Dmel\srn[88]

General Information

Symbol

Dmel\srn⁸⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0117340

Feature type

allele

Associated gene

srn

Associated Insertion(s)

Carried in Construct

Also Known As

stern⁸⁸

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Riede, 2000)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical resistant | dominant

(Riede, 2000)

lethal (with srn^p18)

(Riede, 2000)

lethal (with srn^p21)

(Riede, 2000)

lethal | recessive

(Riede, 1997)

melanotic mass phenotype

(Riede, 2000)

melanotic mass phenotype | recessive

(Riede, 1997)

neoplasia | recessive

(Riede, 1997)

Phenotype Manifest In

larval brain

(Riede, 1997)

melanotic mass

(Riede, 2000, Riede, 1997)

polytene chromosome

(Riede, 1997)

salivary gland

(Riede, 2000, Riede, 1997)

Detailed Description

Statement

Reference

Shows third larval instar lethality when heterozygous with the MBT chromosome. Brain tumours are seen.

(Riede, 2001)

Lethal and tumour inducing over the MBT chromosome. Homozygotes show the formation of few and small melanotic tumours. Gaps in somatic pairing are seen in the polytene chromosomes of heterozygous salivary glands. Heterozygotes show resistance to 5mM hydroxyurea but not to 1mM methyl methanesulfonate.

(Riede, 2000)

Shows strong somatic pairing defect in the salivary chromosomes. Causes weak melanotic tumor formation in larvae. Shows a dominant cell adhesion deficiency in the salivary glands when placed in acidic medium. Shows tumor formation when heterozygous with the MBT chromosome.

(Riede, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

srn⁸⁸ is an enhancer of lethal | embryonic stage phenotype of Antp^Aus

(Riede, 2004)

Other