FlyBase Allele Report: Dmel\Sry-δ[14]

General Information

Symbol

Dmel\Sry-δ¹⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0016087

Feature type

allele

Associated gene

Dmel\Sry-δ

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Payre et al., 1994, Crozatier et al., 1992)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G20A. Amino acid replacement: C7Y.

(Crozatier et al., 1992)

sequenced by Crozatier et al., 1992

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:30,043,498..30,043,498 [+]

Nucleotide change:

G30043498A

Reported nucleotide change:

G20A

Amino acid change:

C7Y | Sry-delta-PA

Reported amino acid change:

C7Y

(Crozatier et al., 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Crozatier et al., 1992)

lethal | recessive

(Ferrer et al., 1994, Payre et al., 1994)

Phenotype Manifest In

cephalopharyngeal skeleton

(Crozatier et al., 1992)

Detailed Description

Statement

Reference

Midgut phenotype is wild type.

(Bilder and Scott, 1995)

Approximately 40% of hemizygous embryos survive, but die as first instar larvae. Some of these hemizygotes have defects in the head skeleton.

(Crozatier et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Sry-δ¹⁴ has lethal phenotype, suppressible by Dpse\Sry-delta^tFa

(Ferrer et al., 1994)

NOT Suppressor of

Statement

Reference

Sry-β::Sry-δ^DB56, Sry-δ¹⁴, Df(3R)X3F is a non-suppressor of visible | homeotic phenotype of mira^{Δ103.αTub67C.mGFP6}

(Irion et al., 2006)

Other

Statement

Reference

Dpse\Sry-delta^tFa, Sry-δ¹⁴ has partially lethal phenotype

(Ferrer et al., 1994)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Sry-β::Sry-δ^DB56, Sry-δ¹⁴, Df(3R)X3F is a non-suppressor of embryonic abdomen | ectopic phenotype of mira^{Δ103.αTub67C.mGFP6}

(Irion et al., 2006)

Sry-β::Sry-δ^DB56, Sry-δ¹⁴, Df(3R)X3F is a non-suppressor of embryonic head phenotype of mira^{Δ103.αTub67C.mGFP6}

(Irion et al., 2006)

Sry-β::Sry-δ^DB56, Sry-δ¹⁴, Df(3R)X3F is a non-suppressor of embryonic thorax phenotype of mira^{Δ103.αTub67C.mGFP6}

(Irion et al., 2006)

Sry-β::Sry-δ^DB56, Sry-δ¹⁴, Df(3R)X3F is a non-suppressor of primordial germ cell | ectopic phenotype of mira^{Δ103.αTub67C.mGFP6}

(Irion et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Embryos that express mira^{Δ103.αTub67C.T:Avic\GFP-m6} and Sry-β::Sry-δ^DB56 in a Sry-δ¹⁴/Df(3R)X3F background show that same phenotype as embryos that express mira^{Δ103.αTub67C.T:Avic\GFP-m6} in a wild-type background.

(Irion et al., 2006)

Xenogenetic Interactions

Statement

Reference

Lethality is largely rescued by one copy of Dpse\Sry-δ^tFa.

(Ferrer et al., 1994)

Complementation and Rescue Data

Rescued by

Sry-δ¹⁴ is rescued by Sry-δ^CH8

(Crozatier et al., 1992)

Sry-δ¹⁴ is rescued by Sry-δ^CH2

(Crozatier et al., 1992)

Comments

Rescued by Sry-δ^CH8 and Sry-δ^CH2.

(Crozatier et al., 1992)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Kongsuwan, Vincent, Lengyel and Merriam.

Comments

Introduction of P{sryDB56,ry⁺} causes partial rescue of the mutant phenotype, thoracic segments are missing, elements of telson are duplicated and segmentation defects in the anterior abdomen.

(Payre et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sry-δ¹⁴

sry-δ¹⁴

(Irion and St Johnston, 2007, Irion and St Johnston, 2007, Irion et al., 2006)

δ14

(Ferrer et al., 1994)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

Open Close