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General Information
Symbol
Dmel\sta2
Species
D. melanogaster
Name
FlyBase ID
FBal0016162
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
stalt3
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous larvae can survive to the third instar stage although they show a considerable delay in development. These third instar larvae tend to die early if they are left in the food, but they can survive in a humid chamber as relatively under-developed third instar larvae for up to 2 weeks after their heterozygous siblings have emerged from the pupal case. The larvae then gradually die without forming a puparium. The hematopoietic organs are considerably enlarged in aged larvae, with the maximum hyperplasia occurring in the first lobes. The hematopoietic organs retain a globular and compact structure. Imaginal discs are small. Melanotic masses are not seen.

The lethal period of development starts at the first larval instar and lasts the whole period of development, with a peak at the prepupal stage. Pupariation is delayed for 60-80 hours and is abnormal; some animals do not show pupal moulting and die at the stage of gas-bubble formation, others die at the stage of eye pigmentation and bristle formation. Those surviving to imago formation generally die before or at the moment of eclosion, while the 2-5% that manage to eclose live for only a few days. Injection of ecdysterone into homozygous 140 hour larvae partially normalises development; puparium formation is not delayed, but subsequent development stops and the imago does not eclose.

Fertility is unaffected.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

sta2 has lethal | recessive | larval stage phenotype, enhanceable by RpS21k16814

Enhancer of
Statement
Reference

sta2 is an enhancer of lethal | recessive | larval stage phenotype of RpS21k16814

Dp(1;3)sta/sta2 is an enhancer of visible | dominant phenotype of RpS21k16814

sta1/sta2 is an enhancer of visible | dominant phenotype of RpS21k16814

Phenotype Manifest In
Enhancer of
Statement
Reference

Dp(1;3)sta/sta2 is an enhancer of macrochaeta phenotype of RpS21k16814

sta1/sta2 is an enhancer of macrochaeta phenotype of RpS21k16814

Additional Comments
Genetic Interactions
Statement
Reference

sta2/Y ; RpS21k16814/RpS21k16814 animals die as first to second instar larvae. sta2/Y ; RpS21k16814/+ and sta2/sta2 ; RpS21k16814/+ animals die as first to second instar larvae. sta2/+ ; RpS21k16814/RpS21k16814 third instar larvae are larger in size and have much larger overgrown imaginal discs than RpS21k16814/RpS21k16814 larvae. The leg discs tend to fuse together and the hematopoietic organs are larger than in RpS21k16814/RpS21k16814 larvae. The sta2/+ ; RpS21k16814/RpS21k16814 third instar larvae are more active than RpS21k16814/RpS21k16814 third instar larvae. The bristle phenotype of RpS21k16814/+ heterozygotes is enhanced by sta2; Dp(1;3)sta/+ or sta1/sta2.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

Mutant phenotype can be resuced by P-element mediated introduction of a wild type copy of sta.

in combination with variegating translocation (T(1;2)dorvar7) produces incised wing margins, small rough eyes with missing facets and missing head macrochaetae (Demakova and Belyaeva, 1988).

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)