FlyBase Allele Report: Dmel\sv[n]

General Information

Symbol

Dmel\svⁿ

Species

D. melanogaster

Name

naked

FlyBase ID

FBal0016607

Feature type

allele

Associated gene

Dmel\sv

Associated Insertion(s)

flea{}svⁿ

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

loss of function allele

(Kavaler et al., 1999)

Mutagen

spontaneous

(Mohr, 1933)

Progenitor genotype

Associated Insertion(s)

flea{}svⁿ

Cytology

Description

Insertion of a 5.0kb flea element within a 0.25kb EcoRI fragment approximately 1.6kb upstream of the transcription start site.

(Fu et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible (with sv^rugoso-nu)

(Sousa-Neves et al., 2005)

visible | recessive

(Kavaler et al., 1999, Fu et al., 1998)

Phenotype Manifest In

chaeta (with sv^rugoso-nu)

(Sousa-Neves et al., 2005)

interommatidial bristle

(Fu et al., 1998)

macrochaeta

(Kavaler et al., 1999, Fu et al., 1998)

microchaeta

(Fu et al., 1998)

scutum & macrochaeta

(Kavaler et al., 1999)

scutum & macrochaeta & trichogen cell

(Kavaler et al., 1999)

scutum & microchaeta

(Kavaler et al., 1999)

scutum & microchaeta & trichogen cell

(Kavaler et al., 1999)

Detailed Description

Statement

Reference

sv^rugoso-nu/svⁿ flies show loss of hairs.

(Sousa-Neves et al., 2005)

svⁿ/Df(4)G flies have more severe bristle defects than svⁿ homozygotes. Homozygotes show bristle defects over the entire body surface. The microchaetae and macrochaetae of the notum often have stunted or misshapen shafts. Macrochaetae also occasionally show a double socket phenotype.

(Kavaler et al., 1999)

sv^spa-20 strongly enhances the bristle phenotype of svⁿ in transheterozygotes; in the eyes there is nearly complete loss of bristle shafts, and in other parts of the body, loss or reduction of the shafts of microchaetae and macrochaetae is more severe than in svⁿ homozygotes. The bristle phenotype of svⁿ mutants is entirely rescued on the notum, partially rescued in the eye and not rescued on the abdomen by sv^2.0.cFa.

(Fu et al., 1998)

Extremely short bristles. Viability excellent. Trichogen irregularly displaced, becoming more or less converted into tormogen (Lees and Waddington, 1943). Polarity of microchaetae in vicinity of double sockets disrupted such that they form a whorl around socket (Toney and Thompson, 1980). In triplo-4 svⁿ/svⁿ/svⁿ, the phenotype is more nearly normal than in diplo-4. RK1. Selective advantage for triplo-4 in stocks of svⁿ results in accumulation.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

svⁿ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sv^rugoso-nu

(Sousa-Neves et al., 2005)

Rescued by

svⁿ/sv^spa-20 is rescued by sv^6.7.cFa

(Fu et al., 1998)

svⁿ is rescued by sv^6.7.cFa

(Fu et al., 1998)

Partially rescued by

svⁿ is partially rescued by sv^2.0.cFa

(Fu et al., 1998)

svⁿ is partially rescued by sv^hs.PF

(Fu et al., 1998)

Comments

The bristle phenotype of svⁿ or svⁿ/sv^spa-20 mutants is completely rescued by sv^6.7.cFa. The bristle phenotype of svⁿ mutants is entirely rescued on the notum and partially rescued in the eye by expression of sv^hs.PF using heat shock.

(Fu et al., 1998)

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type