FlyBase Allele Report: Dmel\Sxl[f2]

General Information

Symbol

Dmel\Sxl^f2

Species

D. melanogaster

Name

FlyBase ID

FBal0016681

Feature type

allele

Associated gene

Dmel\Sxl

Associated Insertion(s)

?{}Sxl^f2

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Bernstein and Cline, 1994, Lindsley and Zimm, 1992)

loss of function allele

(Maine et al., 1985)

Mutagen

spontaneous

(Lindsley and Zimm, 1992, Maine et al., 1985)

Progenitor genotype

Associated Insertion(s)

?{}Sxl^f2

Cytology

Description

Insertion of approximately 5kb DNA into Sxl. Insertion site is 0.5-1kb distal to the site of P-element insertion in Sxl^fPb.

(Maine et al., 1985)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority live | female | recessive

(Lindsley and Zimm, 1992)

sterile | female

(Lindsley and Zimm, 1992)

Phenotype Manifest In

cystoblast

(Tseng et al., 2014)

germarium

(Tseng et al., 2014)

Detailed Description

Statement

Reference

Approximately 20% of Sxl^f2 mutant germaria contain cystoblasts with defects in differentiation.

(Tseng et al., 2014)

All Sxl^f2/Sxl^f4 females can make eggs.

(Sun and Cline, 2009)

Sexual differentiation of external adult tissues in heteroallelic escaper females carrying Sxl^fPRJ2 or Sxl^fLS is normal. Sexual differentiation of homozygous escaper females is also normal, as is the differentiation of clones of homozygous Sxl^f2 tissue in a heterozygous background. Nonetheless escaper females have rudimentary gonads that are covered with testes sheath tissue. Sxl^fPRJ2/Sxl^f1 shows wild type dosage compensation in run²⁵ phenotype assay.

(Bernstein and Cline, 1994)

Some escaper adult females.

(Hilfiker et al., 1994)

Homozygous females are either inviable or very poorly viable, depending on genetic background. Escapers are invariably sterile but otherwise display no obvious sexual abnormalities. Homozygotes defective in dosage compensation as indicated by hyperincorporation of uridine by their polytene chromosomes. Allele fails to support oogenesis in germ-line clones induced by mitotic recombination.

(Lindsley and Zimm, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Sxl^f2 is a non-suppressor of decreased fecundity | dominant | female phenotype of ovo^D2

(Oliver et al., 1990)

Other

Statement

Reference

Sxl^f4/Sxl^f2, otu¹⁷ has female sterile | dominant phenotype

(Sun and Cline, 2009)

Sxl^f2, mle⁴ has abnormal sex-determination | dominant | female phenotype

(Skripsky and Lucchesi, 1982)

Sxl^f2, mle⁴ has visible | dominant | female phenotype

(Skripsky and Lucchesi, 1982)

Sxl^f2, mle⁴ has abnormal sex-determination | female phenotype

(Skripsky and Lucchesi, 1982)

Sxl^f2, mle⁴ has visible | female phenotype

(Skripsky and Lucchesi, 1982)

Phenotype Manifest In

Other

Statement

Reference

Sxl^f2, mle⁴ has prothoracic metatarsus | female phenotype

(Skripsky and Lucchesi, 1982)

Additional Comments

Genetic Interactions

Statement

Reference

Almost no Sxl^f2/Sxl^f4 females make eggs if they also carry otu¹⁷/+. Most egg chambers in these females are tumorous.

(Sun and Cline, 2009)

The number of vitellogenic eggs produced by ovo^D2 heterozygous females is not increased by Sxl^f2.

(Oliver et al., 1990)

Intersexes are seen in females which are homozygous for mle⁴ and are transheterozygous for Sxl^f1 and Sxl^fhv1. Occasionally females heterozygous for Sxl^f2 and homozygous for mle⁴ (at 18^oC) or msl-1^unspecified have sex combs on the basitarsi of their forelegs.

(Skripsky and Lucchesi, 1982)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Sxl^f2593

(Lindsley and Zimm, 1992)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

4593

107814

Notes on Origin

Discoverer

Zimmering and Muller, 1961.

(Lindsley and Zimm, 1992)

Comments

Complements Sxl^f9, and partially complements Sxl^fLS, Sxl^f7,M1 and Sxl^f2 for female viability. Defective in Sxl Pm-mediated activities - the later functions governing maintenance and expression of the female-committed developmental state. Autoregulatory activity involved in maintaining the female determined state is wild type for external somatic tissues, as assayed by interaction with snf.

(Bernstein and Cline, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Fl²

(Lindsley and Zimm, 1992)

Fl^s

(Lindsley and Zimm, 1992)

Sxl^f#2

(Skripsky and Lucchesi, 1982)

Sxl^f2

(Grmai et al., 2018, Sun and Cline, 2009)

sxl^f2

(Tseng et al., 2014)

Name Synonyms

Female lethal-sterile

(Lindsley and Zimm, 1992)

Secondary FlyBase IDs

References (13)

Report Sections

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