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General Information
Symbol
Dmel\tuh1h
Species
D. melanogaster
Name
head defects
FlyBase ID
FBal0017276
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
tuh-1h
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Females homozygous for tuh1h produce adult offspring with significantly more bristles than homozygous tuh1g or tuh1g/tuh1h females. Increased bristle number occurs in the head, thorax and anterior and posterior abdomen. tuh1h is completely recessive to tuh1g. The phenotype is temperature sensitive, with the difference in bristle number between the offspring of tuh1h and tuh1g homozygous females being greatest at 18oC. tuh1h/Df(1)JC4 and tuh1h/Df(1)GA37 females produce offspring with high bristle number. Flies homozygous for tuh1h develop significantly faster than flies heterozygous or homozygous for tuh1g at 18oC, although there is no significant difference in developmental time at 25oC.

Abd-Biab9-tuh-3 females deficient for tuh1h produce offspring with head defects and normal genitalia, just like homozygotes for tuh1h.

Maternal effect gene.

tuh1h/tuh1h Abd-Biab7-SGA/Abd-Biab9-tuh-3 flies have a similar phenotype to Abd-Biab7-SGA heterozygotes.

phenotype with Abd-Biab9-tuh-3 : homeotic leg, tergite, or genital tissue in eye-antenna region (penetrance up to 90%). Semidominant (Kuhn and Packert, 1988a and 1988b).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Maternal effect gene. Abd-Biab9-tuh-3 acts as a semidominant allele in combination with tuh1h, causing growths of abdominal and/or genital tissue in the head.

Abd-Biab9-tuh-3 flies also homozygous for tuh1h show eye outgrowths and have a transformation of head structures to genitalia. This phenotype is temperature-sensitive, having increased penetrance at 25 rather than 18oC.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (4)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (9)
Reported As
Name Synonyms
head defects
Secondary FlyBase IDs
    References (14)