FlyBase Allele Report: Dmel\tuh1[h]

General Information

Symbol

Dmel\tuh1^h

Species

D. melanogaster

Name

head defects

FlyBase ID

FBal0017276

Feature type

allele

Associated gene

tuh1

Associated Insertion(s)

Carried in Construct

Also Known As

tuh-1^h

Key Links

Allele class

loss of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

loss of function allele

(Kuhn et al., 1993)

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | maternal effect | recessive | cold sensitive

(Packert and Kuhn, 1998)

Phenotype Manifest In

macrochaeta | maternal effect | cold sensitive

(Packert and Kuhn, 1998)

Detailed Description

Statement

Reference

Females homozygous for tuh1^h produce adult offspring with significantly more bristles than homozygous tuh1^g or tuh1^g/tuh1^h females. Increased bristle number occurs in the head, thorax and anterior and posterior abdomen. tuh1^h is completely recessive to tuh1^g. The phenotype is temperature sensitive, with the difference in bristle number between the offspring of tuh1^h and tuh1^g homozygous females being greatest at 18^oC. tuh1^h/Df(1)JC4 and tuh1^h/Df(1)GA37 females produce offspring with high bristle number. Flies homozygous for tuh1^h develop significantly faster than flies heterozygous or homozygous for tuh1^g at 18^oC, although there is no significant difference in developmental time at 25^oC.

(Packert and Kuhn, 1998)

Abd-B^iab9-tuh-3 females deficient for tuh1^h produce offspring with head defects and normal genitalia, just like homozygotes for tuh1^h.

(Kuhn et al., 1993)

Maternal effect gene.

(Kuhn and Woods, 1982)

tuh1^h/tuh1^h Abd-B^iab7-SGA/Abd-B^iab9-tuh-3 flies have a similar phenotype to Abd-B^iab7-SGA heterozygotes.

(Awad et al., 1981)

phenotype with Abd-B^iab9-tuh-3 : homeotic leg, tergite, or genital tissue in eye-antenna region (penetrance up to 90%). Semidominant (Kuhn and Packert, 1988a and 1988b).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Abd-B^iab9-tuh-3, tuh1^h has visible | dominant phenotype

(Karch et al., 1985)

Abd-B^iab9-tuh-3, tuh1^h has neoplasia | dominant phenotype

(Karch et al., 1985)

Abd-B^iab9-tuh-3, tuh1^h has visible | semidominant phenotype

(Kuhn et al., 1984)

Abd-B^iab9-tuh-3, tuh1^h has visible | heat sensitive phenotype

(Bownes et al., 1981)

Phenotype Manifest In

Enhanced by

Statement

Reference

tuh1^h has phenotype, enhanceable by E(tuh-1)¹

(Nickla and Carney, 1984)

Other

Statement

Reference

Abd-B^iab9-tuh-3, tuh1^h has embryonic head phenotype

(Mack et al., 1997)

Abd-B^iab9-tuh-3, tuh1^h has genitalia | ectopic phenotype

(Karch et al., 1985, Kuhn et al., 1984, Bownes et al., 1981)

Abd-B^iab9-tuh-3, tuh1^h has head phenotype

(Karch et al., 1985, Kuhn et al., 1984)

Abd-B^iab9-tuh-3, tuh1^h has abdomen | ectopic phenotype

(Kuhn et al., 1984)

Abd-B^iab9-tuh-3, tuh1^h has eye phenotype

(Bownes et al., 1981)

Abd-B^iab9-tuh-3, tuh1^h has adult head phenotype

(Bownes et al., 1981)

Additional Comments

Genetic Interactions

Statement

Reference

Maternal effect gene. Abd-B^iab9-tuh-3 acts as a semidominant allele in combination with tuh1^h, causing growths of abdominal and/or genital tissue in the head.

(Kuhn et al., 1984)

Abd-B^iab9-tuh-3 flies also homozygous for tuh1^h show eye outgrowths and have a transformation of head structures to genitalia. This phenotype is temperature-sensitive, having increased penetrance at 25 rather than 18^oC.

(Bownes et al., 1981)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

674

tuh1^h; Abd-B^iab9-tuh-3

Kyoto

101915

tuh1^h ; Abd-B^iab9-tuh-3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

tu-1

tuh-1

(Bownes et al., 1981)

tuh-1^h

(Packert and Kuhn, 1998, Mack et al., 1997, Nickla and Carney, 1984, Kuhn and Woods, 1982)

tuh-1[h]

(Packert et al., 2006)

tuh-1h

(Kuhn et al., 1984)

tuh1

(Awad et al., 1981)

tuh1¹

tuh1^h

Name Synonyms

head defects

Secondary FlyBase IDs

References (14)

Report Sections

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