FlyBase Allele Report: Dmel\tup[1]

Many antero-dorsal antennal lobe projection neurons (adPN) in tup¹ homozygous somatic clones fail to target the correct glomeruli although in some cases (antennal glomeruli D and VA1d) targeting occur correctly. Mis-targeted dendrites from these neurons frequently end up occupying glomeruli DA1. Many lateral antennal lobe projection neurons (lPN) in these clones are also mis-targeted with a fraction of the dendrites ending up in the subesophageal ganglion and others spread diffusely throughout the antennal lobe. However, targeting of DA1 and DL3 by lPN occurs normally. Targeting of ventral antennal lobe projection neurons (vPN) in these clones occurs normally.

(Komiyama and Luo, 2007)

tup¹ die as embryos with a prominent dorsal hole.

(Biryukova and Heitzler, 2005)

In tup¹ mutant embryos the dorsal trunk is continuous and secondary branching is indistinguishable from wild-type.

(Wilk et al., 2000)

The posterior half of the abdomen is folded back on the anterior half, due to a failure of germband retraction, resulting in an eponymous phenotype. At full germband extension A8 is often opposite A2. Head involution fails. Some components of the head skeleton are absent or rudimentary, including the dorsal arms, dorsal bridge and vertical plate. The filzkorper are often widely separated. Anti-β-tubulin staining reveals a premature loss of amnioserosa cells after stage 11. The amnioserosa does not undergo programmed cell death.

(Frank and Rushlow, 1996)

Homozygous embryos exhibit an intermediate germband retraction defective phenotype. Kr staining reveals abnormalities in the amnioserosa.

(Goldman-Levi et al., 1996)

Germband retraction and dorsal closure fail to occur in homozygous embryos.

(Strecker et al., 1995)

Nondefective in gonad assembly.

(Warrior, 1994)

Does not interact with RpII140^wimp maternal effect.

(Parkhurst and Ish-Horowicz, 1991)

Suppression of tor^13D embryos: increase in proportion of embryos that formed cuticle and decrease in proportion of embryos that formed empty sacs.

(Strecker et al., 1991)

apparently ceases early, resulting in the posteriormost three segments remaining on dorsal side of the embryo. embryonic lethal. Head broad. Germband shortening

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

SoxN^GA1192, tup¹/tup[+] has partially lethal phenotype

(Girard et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

tup¹ has phenotype, enhanceable by ush²

(Goldman-Levi et al., 1996)

Enhancer of

Statement

Reference

tup¹/tup[+] is an enhancer of thorax phenotype of Chi^E

(Biryukova and Heitzler, 2005)

tup¹/tup[+] is an enhancer of scutellar bristle | increased number phenotype of Chi^E

(Biryukova and Heitzler, 2005)

tup¹ is an enhancer of phenotype of ush²

(Goldman-Levi et al., 1996)

Suppressor of

Statement

Reference

tup¹ is a suppressor of embryonic/first instar larval cuticle | maternal effect phenotype of tor^12D

(Li and Li, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

tup¹ enhances the excess scutellar bristle and thoracic cleft phenotype of Chi^E flies when heterozygous.

(Biryukova and Heitzler, 2005)

Germ band retraction defects are more severe than the single homozygote when in combination with ush².

(Goldman-Levi et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

36503

y¹ w^*; tup¹ P{neoFRT}40A/CyO

2207

tup¹ cn¹ bw¹ speck¹/CyO

Kyoto

106739

tup¹ cn¹ bw¹ speck¹/CyO

Notes on Origin

Discoverer

Comments

Both midgut primordia extend normally along the visceral mesoderm and the yolk is completely engulfed by the endoderm.

(Reuter et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

isl¹

(Layden et al., 2006)

isl^IIIB29

(Biryukova and Heitzler, 2005)

tup¹

(Anllo et al., 2019, Santiago and Bashaw, 2017, Stagg et al., 2011, Benito-Sipos et al., 2010, Christensen et al., 2008.4.15, de Navascués and Modolell, 2007, Komiyama and Luo, 2007, Roshina and Pasyukova, 2007, Tao et al., 2007, Girard et al., 2006)

tup^IIIB29

(Goldman-Levi et al., 1996, Harbecke and Lengyel, 1995, Parkhurst and Ish-Horowicz, 1991, Strecker et al., 1991)

tup^IIIB

(Frank and Rushlow, 1996, Strecker et al., 1995, Warrior, 1994, Tearle and Nusslein-Volhard, 1987)

tup^isl1

(Bivik et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (28)

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