FlyBase Allele Report: Dmel\w[co]

General Information

Symbol

Dmel\w^co

Species

D. melanogaster

Name

coral

FlyBase ID

FBal0018225

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

Transpac{}w^co

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lloyd et al., 2002)

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

Transpac{}w^co

Cytology

Description

Antiparallel Transpac insertion into intron 5.

(Csink et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Lloyd et al., 2002, Bhadra et al., 1997)

abnormal eye color | recessive

(Frolov et al., 1998)

decreased efficacy of short-term memory | adult stage

(Myers et al., 2021)

visible | recessive

Phenotype Manifest In

Malpighian tubule

pigment cell

(Lloyd et al., 2002, Frolov et al., 1998)

Detailed Description

Statement

Reference

w^co adults exhibit decreased short term memory in one-trail olfactory associative learning protocol.

(Myers et al., 2021)

Homozygotes have dull red eyes with 26% red pigment (compared to 100% pigment in wild type).

(Lloyd et al., 2002)

Eye colour: deep ruby in male, darkening to g-like; lighter in female. Malpighian tubule colour: pale yellow.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

w^co has abnormal eye color | recessive phenotype, suppressible by Rga[+]/Rga⁰³⁸³⁴

(Frolov et al., 1998)

w^co has abnormal eye color | recessive phenotype, suppressible by Low¹

(Bhadra et al., 1997)

Enhancer of

Statement

Reference

w^co/w^e(g) is an enhancer of abnormal eye color phenotype of g^50e

(Lloyd et al., 2002)

w^co/w^e(g) is an enhancer of abnormal eye color phenotype of g^53d

(Lloyd et al., 2002)

w^co/w^e(g) is an enhancer of abnormal eye color phenotype of g²

(Lloyd et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

w^co has phenotype, enhanceable by Mow^gamma

(Bhadra and Birchler, 1996)

w^co has phenotype, enhanceable by Wow^γb

(Birchler et al., 1994)

w^co has phenotype, enhanceable by Wow^γe

(Birchler et al., 1994)

w^co has phenotype, enhanceable by Wow^ems1

(Birchler et al., 1994)

w^co has phenotype, enhanceable by Wow^hd1

(Birchler et al., 1994)

w^co has phenotype, enhanceable by Rm62^D

(Csink et al., 1994)

w^co has phenotype, enhanceable by Rm62^Dem

(Csink et al., 1994)

w^co has phenotype, enhanceable by Rm62^E

(Csink et al., 1994)

w^co has phenotype, enhanceable by Rm62^F

(Csink et al., 1994)

w^co has phenotype, enhanceable by Rm62^H

(Csink et al., 1994)

w^co has phenotype, enhanceable by Rm62^K

(Csink et al., 1994)

w^co has phenotype, enhanceable by e(w^e)¹

NOT Enhanced by

Statement

Reference

w^co has phenotype, non-enhanceable by Kr-h1⁰⁵²⁰⁸

(Benevolenskaya et al., 2000)

w^co has phenotype, non-enhanceable by Ufo¹

(Bhadra et al., 1997)

w^co has phenotype, non-enhanceable by In(3)Msu¹

(Csink et al., 1994)

w^co has phenotype, non-enhanceable by In(3)Msu²

(Csink et al., 1994)

w^co has phenotype, non-enhanceable by E(w^a)¹

(Birchler and Hiebert, 1989)

w^co has phenotype, non-enhanceable by Doa^HD

(Rabinow and Birchler, 1989)

w^co has phenotype, non-enhanceable by Doa³

(Rabinow and Birchler, 1989)

w^co has phenotype, non-enhanceable by Doa⁴

(Rabinow and Birchler, 1989)

w^co has phenotype, non-enhanceable by Doa⁵

(Rabinow and Birchler, 1989)

w^co has phenotype, non-enhanceable by Doa⁶

(Rabinow and Birchler, 1989)

w^co has phenotype, non-enhanceable by Doa⁷

(Rabinow and Birchler, 1989)

w^co has phenotype, non-enhanceable by Doa⁸

(Rabinow and Birchler, 1989)

w^co has phenotype, non-enhanceable by Doa⁹

(Rabinow and Birchler, 1989)

Suppressed by

Statement

Reference

w^co has pigment cell phenotype, suppressible by Rga[+]/Rga⁰³⁸³⁴

(Frolov et al., 1998)

w^co has pigment cell phenotype, suppressible by Low¹

(Bhadra et al., 1997)

NOT suppressed by

Statement

Reference

w^co has phenotype, non-suppressible by Kr-h1⁰⁵²⁰⁸

(Benevolenskaya et al., 2000)

w^co has phenotype, non-suppressible by Ufo¹

(Bhadra et al., 1997)

w^co has phenotype, non-suppressible by In(3)Msu¹

(Csink et al., 1994)

w^co has phenotype, non-suppressible by In(3)Msu²

(Csink et al., 1994)

w^co has phenotype, non-suppressible by Doa⁷

(Rabinow and Birchler, 1989)

w^co has phenotype, non-suppressible by Doa⁸

(Rabinow and Birchler, 1989)

w^co has phenotype, non-suppressible by Doa⁹

(Rabinow and Birchler, 1989)

w^co has phenotype, non-suppressible by Doa^HD

(Rabinow and Birchler, 1989)

w^co has phenotype, non-suppressible by Doa³

(Rabinow and Birchler, 1989)

w^co has phenotype, non-suppressible by Doa⁴

(Rabinow and Birchler, 1989)

w^co has phenotype, non-suppressible by Doa⁵

(Rabinow and Birchler, 1989)

w^co has phenotype, non-suppressible by Doa⁶

(Rabinow and Birchler, 1989)

w^co has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

w^co/w^e(g) is an enhancer of pigment cell phenotype of g²

(Lloyd et al., 2002)

w^co/w^e(g) is an enhancer of pigment cell phenotype of g^50e

(Lloyd et al., 2002)

w^co/w^e(g) is an enhancer of pigment cell phenotype of g^53d

(Lloyd et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Flies with a w^co/w^e(g) mutant genotype enhance the eye colour defective phenotype of g², g^50e and g^53d homozygous mutants leading to a greater reduction of red pigment in the eye. Male w^co, g^53d double mutant flies have lower levels of pigment in the eye than w^co single mutants, leading to a change in eye colour from dull red to faint yellow.