FlyBase Allele Report: Dmel\hid[1]

General Information

Symbol

Dmel\hid¹

Species

D. melanogaster

Name

FlyBase ID

FBal0018404

Feature type

allele

Associated gene

Dmel\hid

Associated Insertion(s)

Carried in Construct

Also Known As

W¹

Key Links

Allele class

Mutagen

stratosphere

Nature of the Allele

Allele class

Mutagen

stratosphere

(Lindsley and Zimm, 1992)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | P-stage

(Ohta et al., 2022)

viable

(Lindsley and Zimm, 1992)

visible | adult stage

(Ohta et al., 2022)

Phenotype Manifest In

head

(Lindsley and Zimm, 1992)

wing

(Lindsley and Zimm, 1992, Waddington, 1940)

wing | adult stage

(Ohta et al., 2022)

wing | P-stage

(Ohta et al., 2022)

Detailed Description

Statement

Reference

Wings remain small and unexpanded. Black spots on head beside proboscis or ocelli. Heterozygous female like homozygote but less extreme. Male much less extreme; wings often expanded but wrinkled, blistered and surface finely pebbled and grayish; no overlap with wild type. Suppressed by D¹ in male and nearly so in female. RK1 as dominant.

(Lindsley and Zimm, 1992)

From prepupal stage through adult, wing bases abnormally narrow, possibly preventing flow of body fluid in sufficient quantity to expand wings.

(Waddington, 1940)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

hid¹ has increased cell death | P-stage phenotype, suppressible by Scer\GAL4^en-e16E/BacA\p35^UAS.cHa

(Ohta et al., 2022)

hid¹ has visible | adult stage phenotype, suppressible by Scer\GAL4^en-e16E/BacA\p35^UAS.cHa

(Ohta et al., 2022)

Suppressor of

Statement

Reference

W[+]/hid¹ is a suppressor | partially of visible phenotype of mir-bft^unspecified/mir-bft^Δ263a

(Hilgers et al., 2010)

W[+]/hid¹ is a suppressor of abnormal neuroanatomy | adult stage | RU486 conditional phenotype of Lrrk^I1915T.UAS, Scer\GAL4^{elav.Switch.PO}, foxo^UAS.cKb

(Kanao et al., 2010)

W[+]/hid¹ is a suppressor | partially of visible phenotype of Lrrk^I1915T.UAS, Scer\GAL4^GMR.PF, foxo^UAS.cKb

(Kanao et al., 2010)

Phenotype Manifest In

Suppressed by

Statement

Reference

hid¹ has wing | adult stage phenotype, suppressible by Scer\GAL4^en-e16E/BacA\p35^UAS.cHa

(Ohta et al., 2022)

hid¹ has wing | P-stage phenotype, suppressible by Scer\GAL4^en-e16E/BacA\p35^UAS.cHa

(Ohta et al., 2022)

Suppressor of

Statement

Reference

W[+]/hid¹ is a suppressor | partially of interommatidial bristle phenotype of mir-bft^unspecified/mir-bft^Δ263a

(Hilgers et al., 2010)

W[+]/hid¹ is a suppressor of dopaminergic neuron | RU486 conditional phenotype of Lrrk^I1915T.UAS, Scer\GAL4^{elav.Switch.PO}, foxo^UAS.cKb

(Kanao et al., 2010)

W[+]/hid¹ is a suppressor of dopaminergic PPL1 neuron | RU486 conditional phenotype of Lrrk^I1915T.UAS, Scer\GAL4^{elav.Switch.PO}, foxo^UAS.cKb

(Kanao et al., 2010)

W[+]/hid¹ is a suppressor | partially of eye phenotype of Lrrk^I1915T.UAS, Scer\GAL4^GMR.PF, foxo^UAS.cKb

(Kanao et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

W¹/+ partially suppresses the loss of interommatidial bristles which is seen in bft^Δ263a/bft^unspecified flies.

(Hilgers et al., 2010)

The eye phenotype caused by co-expression of foxo^Scer\UAS.cKb and Lrrk^{I1915T.Scer\UAS} under the control of Scer\GAL4^GMR.PF is significantly suppressed by W¹/+.

The degeneration of the PPM1/2 and PPL1 neurons which is seen in flies co-expressing foxo^Scer\UAS.cKb and Lrrk^{I1915T.Scer\UAS} under the control of Scer\GAL4^{elav.Switch.PO} in the presence of RU486 is suppressed if they alo carry W¹/+.

(Kanao et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type