FlyBase Allele Report: Dmel\whd[1]

General Information

Symbol

Dmel\whd¹

Species

D. melanogaster

Name

FlyBase ID

FBal0018515

Feature type

allele

Associated gene

Dmel\whd

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Lindsley and Zimm, 1992)

Progenitor genotype

Cytology

Description

16bp deletion in exon 2 (coordinates +55 through +70), which produces a frameshift that results in a stop codon in exon 3.

(Strub et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:10,473,340..10,473,355 [-]

Comment:

16bp deletion in exon 2 (coordinates +55 through +70), which produces a frameshift that results in a stop codon in exon 3.

(Strub et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | larval stage

(Tiwari et al., 2020)

abnormal immune response | adult stage

(Von Ohlen et al., 2012)

abnormal size | larval stage

(Tiwari et al., 2020)

chemical sensitive

(Logan-Garbisch et al., 2014, Strub et al., 2008)

increased occurrence of cell division | larval stage

(Tiwari et al., 2020)

partially lethal | chemical conditional

(Logan-Garbisch et al., 2014)

radiation sensitive

(Strub et al., 2008)

viable

(Strub et al., 2008)

visible (with whd²)

(Strub et al., 2008)

visible (with whd³)

(Strub et al., 2008)

visible (with whd⁴)

(Strub et al., 2008)

visible (with whd⁵)

(Strub et al., 2008)

visible (with whd⁶)

(Strub et al., 2008)

visible (with whd⁷)

(Strub et al., 2008)

visible (with whd⁸)

(Strub et al., 2008)

visible (with whd⁹)

(Strub et al., 2008)

visible (with whd¹⁰)

(Strub et al., 2008)

visible (with whd¹¹)

(Strub et al., 2008)

visible (with whd¹²)

(Strub et al., 2008)

visible (with whd¹³)

(Strub et al., 2008)

visible (with whd¹⁴)

(Strub et al., 2008)

visible | recessive

(Strub et al., 2008)

Phenotype Manifest In

cortical zone of lymph gland primary lobe | larval stage

(Tiwari et al., 2020)

embryonic/larval crystal cell | decreased number | larval stage

(Tiwari et al., 2020)

embryonic/larval plasmatocyte | decreased number | larval stage

(Tiwari et al., 2020)

primary lobe of embryonic/larval lymph gland | larval stage

(Tiwari et al., 2020)

wing

(Strub et al., 2008, Lindsley and Zimm, 1992)

wing (with whd²)

(Strub et al., 2008)

wing (with whd³)

(Strub et al., 2008)

wing (with whd⁴)

(Strub et al., 2008)

wing (with whd⁵)

(Strub et al., 2008)

wing (with whd⁶)

(Strub et al., 2008)

wing (with whd⁷)

(Strub et al., 2008)

wing (with whd⁸)

(Strub et al., 2008)

wing (with whd⁹)

(Strub et al., 2008)

wing (with whd¹⁰)

(Strub et al., 2008)

wing (with whd¹¹)

(Strub et al., 2008)

wing (with whd¹²)

(Strub et al., 2008)

wing (with whd¹³)

(Strub et al., 2008)

wing (with whd¹⁴)

(Strub et al., 2008)

Detailed Description

Statement

Reference

whd¹ homozygous lymph gland primary lobes have abundant Dome[+] progenitors but drastically reduced number of differentiated hemocytes (plasmatocytes and crystal cells), and Intermediate progenitors (Dome[+] Pxn[+]). They exhibit an increase in proliferation of hemocyte progenitors in the lymph gland primary lobe.

(Tiwari et al., 2020)

whd¹ homozygotes show increased mortality when exposed to 7% ethanol during development compared to controls.

(Logan-Garbisch et al., 2014)

Mutant flies show significantly increased survival compared to wild-type flies after infection with E. chaffeensis. Bacterial replication is significantly reduced in the mutant flies compared to wild type.

(Von Ohlen et al., 2012)

Homozygotes are highly sensitive to both ionizing radiation and dietary paraquat compared to controls.

Homozygotes have a weak mutant wing phenotype.

Mutants show no significant difference in longevity compared to control flies.

(Strub et al., 2008)

Wings warped and waved or reduced to shrunken black pupal pads. Synthetic lethal in presence of su(r). RK2.

(Lindsley and Zimm, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class