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General Information
Symbol
Dmel\ry506
Species
D. melanogaster
Name
FlyBase ID
FBal0015008
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Inserted_sequence:

A

Comment:

A deletion of approximately one-third of the coding region beginning at the sequence GTGCATTG and ending at TTATGAAAC. There is an insertion of a single A between the breakpoints.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

The ry506 deletion begins at +1397 (GTGCATTG...) and proceeds through +4885 (...TTATGAAAC). There is an insertion of a single A between the breakpoints (unless this A is a polymorphism on the ry+5 chromosome at +4885).

Deletion of two thirds of the 3' end of the gene.

3.4 kb deletion between +1.1 and +5.0 kb.

Deletion mutant.

The 3' half of the coding region is deleted.

Deletion of approximately one-third of the coding region.

Deletion of ry coding sequences.

Deletion of ry sequences, including at least some of the protein coding region.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

21-days old ry506 mutant adults raised at 29[o]C do not show significantly changes in PPL1 neurons, as compared to age-matched controls.

ry506 homozygotes show increased mortality but no effect on developmental time when exposed to ethanol during development compared to controls.

The response of ry506 mutants to paraquat is similar to wild-type flies.

Homozygotes are hypersensitive to paraquat, hyperoxia and γ-radiation. ry506 Sodn1 double homozygotes die during late metamorphosis and during the process of eclosion.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT Enhancer of
Statement
Reference

ry506/ry506 is a non-enhancer of chemical resistant | dominant phenotype of pucE69

Other
Phenotype Manifest In
Suppressed by
Statement
Reference
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

whd1 ry506 double homozygotes have a much more severe wing phenotype than either single homozygote.

The response of pucE69/+ flies to paraquat is not affected when flies have a ry506 genetic background.

The double mutant combination Zwn1/Y ry506/ry506 or Zwn3/Y ry506/ry506 is usually lethal. Escaper Zwn1/Y ry506/ry506 flies live for only a few days and appear to be sterile.

Xenogenetic Interactions
Statement
Reference

Expression of Ccap\Xdhhs.PP using heat shock in ry506 animals results in flies with wild-type eye pigmentation.

Complementation and Rescue Data
Rescued by
Partially rescued by

ry506 is partially rescued by ry606N

ry506 is partially rescued by ry609N

Comments

One copy of ry+t7.2 restores full viability of homozygous ry506 flies on purine selection.

ry606N and ry609N each rescue wild-type eye colour but not survival on purine selection in ry506 flies.

Images (2)
Stocks (1,651)
Notes on Origin
Discoverer
Comments
Comments

Dia2 enzyme activity is missing in ry506 mutants.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (35)