FB2026_02 , released June 18, 2026
Allele: Dmel\cue2
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General Information
Symbol
Dmel\cue2
Species
D. melanogaster
Name
FlyBase ID
FBal0028140
Feature type
allele
Associated gene
Dmel\cue
Associated Insertion(s)
P{PZ}cue2
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

Mutagen
P-element activity
(Spradling et al., 1999, FlyBase, 1996-, BDGP Project Members, 1994-1999, Castrillon et al., 1993)
Progenitor genotype
Associated Insertion(s)
P{PZ}cue2
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cue2 homozygotes and cue2/Df(3L)Ar14-8 flies exhibit a low sleep rebound following 12 hrs of sleep deprivation, compared to controls.

      cue2 homozygotes show significantly reduced organismal triglyceride stores compared to controls.

      (Thimgan et al., 2015)

      Spermatocytes contain cytoplasmic abnormalities. Rare post-meiotic cysts are defective. Testis are short with a defective sheath. Females are semi-sterile, ovaries are small and misshapen. Phenotypes are more severe when in trans with a deficiency.

      (Castrillon et al., 1993)

      Spermatocytes contain cytoplasmic abnormalities. Rare post-meiotic cysts defective. Testis short with defective sheath. Ovaries small and misshapen. Phenotypes more severe when hemizygous with a deletion.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Complements: l(3)0210402104. Complements: l(3)j6B4j6B4. Complements: l(3)neo41. Complements: l(3)neo51. Complements: l(3)neo61. Complements: l(3)62Be1.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      cue02509
      cue2
      (Thimgan et al., 2015, Christensen et al., 2007.5.8, Gresens and Cook, 2006.8.29)
      ms(3)02509
      (Spradling et al., 1999)
      ms(3)0250902509
      Name Synonyms
      Secondary FlyBase IDs
        References (7)