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General Information
Symbol
Dmel\NM1
Species
D. melanogaster
Name
FlyBase ID
FBal0029949
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

A3164100T

Reported nucleotide change:

A?T

Amino acid change:

E491V | N-PA; E491V | N-PB

Reported amino acid change:

E491V

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: E412V.

Mutation falls in EGF repeat number 12 and affects the Dl binding domain.

Amino acid replacement: E491V. The E491V substitution falls within EGF repeat 12. Only EGF repeats 11 and 12 were examined for mutant lesions.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hemizygous lethal. Heterozygotes have a neurogenic phenotype and have an increase in the number of thoracic bristles compared to wild-type. The number of bristles is restored almost to wild-type in NM1 ; Dp(1;2)51b double heterozygotes.

NM1 defines a new class of Notch allele. Hemizygous embryos die with severe neurogenic phenotype. Shows classic Notch phenotype when transheterozygous with fa and nd classes of alleles. Antimorphism revealed in males where the lethality is rescued by a duplication for Notch but the rescued males retain a wing vein thickening and notched wing phenotype. NM1 shows suppressive interactions with "NAx" alleles of both the enhancer of Notch and suppressor of Notch class, but lethal Abruptex class Notch alleles are lethal when heterozygous with NM1. Suppressive interactions also evident with alleles of the split class of Notch alleles.

Lack of chaetae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

NM1 has visible | dominant phenotype, suppressible by wgS107

Other
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The number of bristles is restored to wild-type in NM1 ; wgS107 double heterozygotes. NM1 ; Df(3R)Dl-FX3 double heterozygotes die before pupation.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Genetic interactions with Delta and Serrate alleles of the Beaded locus suggest that NM1 products have modified binding abilities with both Dl and Bd products. Similarity with and lack of specificity of interaction of N- and NM1 with H, mam, gro and E(spl) suggest that the NM1 effect is due to modification in the intracellular signalling of the activated N receptor.

Shows little or no allele-specific interaction with wgl-12, and no allele-specific interaction with wgl-15, wgS107 or wgS84.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
NM1
Name Synonyms
Secondary FlyBase IDs
    References (7)