FlyBase Allele Report: Dmel\slbo[e7b]

General Information

Symbol

Dmel\slbo^e7b

Species

D. melanogaster

Name

FlyBase ID

FBal0032726

Feature type

allele

Associated gene

Dmel\slbo

Associated Insertion(s)

P{?'PZ}slbo^e7b

Carried in Construct

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(An and Wensink, 1995, Rorth, 1994, Rorth and Montell, 1992)

loss of function allele

(Liu and Montell, 2001, Montell et al., 1992)

Mutagen

Delta2-3 transposase

(Montell et al., 1992, Rorth and Montell, 1992)

Progenitor genotype

slbo⁰¹³¹⁰

(Liu and Montell, 2001, Montell et al., 1992, Rorth and Montell, 1992)

Associated Insertion(s)

P{?'PZ}slbo^e7b

Cytology

Description

Imprecise excision of the P{PZ} element resulting in a deletion of the slbo locus (deletion is of only the slbo locus).

(Liu and Montell, 2001)

Deletion of approximately 5.75kb extending from P element of slbo⁰¹³¹⁰ to beyond slbo transcription unit.

(Rorth and Montell, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell migration | adult stage (with slbo^LY6)

(Starz-Gaiano et al., 2008)

female sterile

(Montell et al., 1992)

lethal | recessive

(An and Wensink, 1995, Montell et al., 1992)

lethal - all die during embryonic stage | recessive

(Rorth and Montell, 1992)

some die during embryonic stage | recessive

(Rorth and Montell, 1992)

Phenotype Manifest In

border follicle cell

(McDonald et al., 2003)

border follicle cell (with slbo⁰¹³¹⁰)

(Borghese et al., 2006, Montell et al., 1992)

border follicle cell (with slbo^LY6)

(Wang et al., 2006)

border follicle cell | oogenesis stage S10 (with slbo^LY6)

(Starz-Gaiano et al., 2008)

egg chamber | oogenesis stage S10 (with slbo^LY6)

(Starz-Gaiano et al., 2008)

Detailed Description

Statement

Reference

slbo^LY6/slbo^e7b mutants fail to initiate border cell movement in stage 10 egg chambers. The border cells remain at the anterior tip of the egg chamber.

(Starz-Gaiano et al., 2008)

Border cells do not migrate in slbo⁰¹³¹⁰/slbo^e7b females.

(Borghese et al., 2006)

Border follicle cells fail to migrate in slbo^LY6/slbo^e7b females.

(Wang et al., 2006)

Border cells migrate only 0-25% of the normal distance in homozygous egg chambers.

(McDonald et al., 2003)

Female sterile over slbo⁰¹³¹⁰ : border cell migration fails completely.

(Montell et al., 1992)

Wild type cuticle pattern, and no obvious morphological defects.

(Rorth and Montell, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

slbo^e7b/slbo^e14a has border follicle cell phenotype, enhanceable by btl^H82Δ3/btl[+]

(Murphy et al., 1995)

slbo^e7b/slbo^e14a has border follicle cell phenotype, enhanceable by btl^LG19/btl[+]

(Murphy et al., 1995)

NOT suppressed by

Statement

Reference

slbo⁰¹³¹⁰/slbo^e7b has border follicle cell phenotype, non-suppressible by jing^hs.PL

(Liu and Montell, 2001)

Additional Comments

Genetic Interactions

Statement

Reference

jing^hs.PL does not rescue the border cell migration defects of slbo⁰¹³¹⁰/slbo^e7b.

(Liu and Montell, 2001)

Border cell migration defect of slbo^e7b/slbo^e14a is dominantly enhanced by btl^H82Δ3 and btl^LG19.

(Murphy et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

slbo^5D4

(Liu and Montell, 1999)

slbo⁰¹³¹⁰

(Montell et al., 1992)

Partially rescued by

slbo^e7b is partially rescued by slbo^B-RR

(Rorth and Montell, 1992)

Not rescued by

slbo^e7b is not rescued by slbo^RRstop

(Rorth and Montell, 1992)

Comments

Lethality can be rescued by P element containing wild type slbo sequences, but not by a derivative in which stop codons replaced amino acids 29 and 30.

(Rorth and Montell, 1992)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

58686

slbo^e7b/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Slbo^e7b

(Wang et al., 2010)

l(2)slbo^e7b

(Hutson and Bownes, 2003)

slbo^1310e7b

(Rorth, 1994)

slbo^e7b

(Dai et al., 2020, Miao et al., 2020, Ogienko et al., 2020, Starz-Gaiano et al., 2008, Levine et al., 2007, Borghese et al., 2006, Wang et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

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