FlyBase Allele Report: Dmel\sog[Y506]

General Information

Symbol

Dmel\sog^Y506

Species

D. melanogaster

Name

FlyBase ID

FBal0032753

Feature type

allele

Associated gene

Dmel\sog

Associated Insertion(s)

Carried in Construct

Also Known As

sog^YS06, sog^SY06

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Ray et al., 1991)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Ferguson and Anderson, 1992)

Phenotype Manifest In

Detailed Description

Statement

Reference

Hemizygous embryos have a dorsalised cuticle containing extremely truncated denticles, a completely U-shaped body, herniated head and Filzkorper defects.

(Stinchfield et al., 2012)

Dorsalisation: Cuticles of sog^Y506 hemizygous embryos show reduction of the dorsal extent of the ventral denticle belts.

(Podos et al., 2001)

A reduction in salivary gland placode is seen in these embryos. The anterior rows of denticle belts are not reduced in these mutants.

(Lammel et al., 2000)

sog^Y506/Y embryos are abnormally shaped due to a failure in germ band extension. The ventral denticle belts are reduced in size (the reduction is less severe than in brk^M68/Y embryos). Defects are seen in the outer row of sna-expressing neuroblasts in the ventral neurogenic region. Only a small number of scattered amnioserosa cells are produced.

(Jazwinska et al., 1999)

Ventralized embryos: rings or patches of ventral denticles along dorsoventral axis. Disruption of germ band extension that leads to the invagination of posterior segments into the interior of the embryo.

(Ray et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

sog^Y506 is a suppressor of lethal phenotype of tld¹/tld¹⁴

(Ferguson and Anderson, 1992)

Phenotype Manifest In

Enhanced by

Statement

Reference

sog^Y506 has larval dorsal hair phenotype, enhanceable by Smurf^15C

(Podos et al., 2001)

sog^Y506 has embryonic/first instar larval cuticle phenotype, enhanceable by Smurf^15C

(Podos et al., 2001)

sog^Y506 has ventral denticle belt phenotype, enhanceable by Smurf^15C

(Podos et al., 2001)

Suppressed by

Statement

Reference

sog^Y506 has embryonic/first instar larval cuticle phenotype, suppressible by dpp^hr4/dpp[+]

(Stinchfield et al., 2012)

sog^Y506 has denticle phenotype, suppressible by dpp^hr4/dpp[+]

(Stinchfield et al., 2012)

sog^Y506 has embryonic/first instar larval cuticle phenotype, suppressible by Med[+]/Med¹⁵

(Stinchfield et al., 2012)

sog^Y506 has denticle phenotype, suppressible by Med[+]/Med¹⁵

(Stinchfield et al., 2012)

sog^Y506 has embryonic/first instar larval cuticle phenotype, suppressible by faf^FO8/faf[+]

(Stinchfield et al., 2012)

sog^Y506 has denticle phenotype, suppressible by faf^FO8/faf[+]

(Stinchfield et al., 2012)

sog^Y506 has amnioserosa phenotype, suppressible by Dp(2;2)DTD48

(Decotto and Ferguson, 2001)

Other

Statement

Reference

brk^M68, sog^Y506 has ventral denticle belt phenotype

(Jazwinska et al., 1999)

brk^M68, sog^Y506 has ventral neurectoderm phenotype

(Jazwinska et al., 1999)

Dp(2;2)DTD48, sog^Y506 has amnioserosa phenotype

(Jazwinska et al., 1999)

Dp(2;2)DTD48, sog^Y506 has ventral neurectoderm phenotype

(Jazwinska et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

dpp^hr4/+ partially suppresses the cuticle phenotype of sog^Y506 hemizygous embryos, partially restoring denticles and producing a curved body.

Med¹⁵/+ partially suppresses the cuticle phenotype of sog^Y506 hemizygous embryos. The embryos have partially restored denticles, a normal body shape and misplaced, misshapen Filzkorper.

faf^FO8/+ partially suppresses the cuticle phenotype of sog^Y506 hemizygous embryos. The embryos have partially restored denticles, a normal body shape and poorly developed Filzkorper.

(Stinchfield et al., 2012)

The mesoderm is able to spread out over the ectoderm after mesoderm invagination in sog^Y506 brk^M68 double mutant embryos. The mesoderm is able to spread out over the ectoderm after mesoderm invagination in Egfr^top-18A sog^Y506 brk^M68 triple mutant embryos.

(Wilson et al., 2005)

The weak dorsalisation phenotype exhibited by cuticles from sog^Y506 hemizygous embryos is enhanced to full dorsalisation (transformation of all ventral denticle belts into dorsal hairs) by maternal and zygotic heterozygosity for lack^15C.

(Podos et al., 2001)

The ectoderm of brk^M68 sog^Y506/Y double mutant embryos forms only dorsal-type cuticle hairs and completely lacks ventral denticles. The ventral neurogenic region is deleted. The amnioserosa defect seen in sog^Y506/Y single mutant embryos is not rescued in the double mutant embryos. sog^Y506/Y Dp(2;2)DTD48/Dp(2;2)DTD48 embryos have a cuticle phenotype resembling that of brk mutants and on average only one row of sna-expressing neuroblasts is left in the ventral neurogenic region. The amnioserosa defect seen in sog^Y506/Y single mutant embryos is rescued in the double mutant embryos and there is a large increase in the number of amnioserosa cells compared to wild type.

(Jazwinska et al., 1999)

Suppressor of the tld¹⁴/tld¹ lethal phenotype. Extra copies of dpp enhance the mutant phenotype causing profound alterations in the cuticular pattern of the neurogenic ectoderm.

(Ferguson and Anderson, 1992)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

sog^SY06

(Xu et al., 2005, Jazwinska et al., 1999)

sog^Y506

(Sandler et al., 2018, Mizutani et al., 2006)

sog^YS06

(Garcia and Stathopoulos, 2011, Lin et al., 2006, Wang and Ferguson, 2005, Wilson et al., 2005, Chang et al., 2001, Podos et al., 2001, Ross et al., 2001, Rushlow et al., 2001, Cremazy et al., 2000, Lammel et al., 2000, von Ohlen and Doe, 2000, Jazwinska et al., 1999, Mason et al., 1997, D'Alessio and Frasch, 1996, Frasch, 1995, Ferguson and Anderson, 1992)

sog^YSO6

(Decotto and Ferguson, 2001)

sog^y506

(Stinchfield et al., 2012)

sogY506

(Dunipace et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (25)

Report Sections

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