FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Syt1T41
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General Information
Symbol
Dmel\Syt1T41
Species
D. melanogaster
Name
FlyBase ID
FBal0032852
Feature type
allele
Associated gene
Dmel\Syt1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Littleton et al., 1994)

loss of function allele

(Littleton et al., 1993)
Mutagen
ethyl methanesulfonate
(Littleton and Bellen, 1994, Littleton et al., 1994, Littleton et al., 1993)
Progenitor genotype
Cytology
Description

No obvious rearrangement as detected by Southern blot.

(Littleton et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Syt1AD3/Syt1T41 synapses have a rate constant that is not statistically different from wild-type controls.

      (Poskanzer et al., 2006)

      sytAD1/sytT41 mutants lack the on-off transients normally seen during electroretinogram recordings in the retina. There is a decrease in the overall number of synaptic vesicles at the photoreceptor synapses in sytAD1/sytT41 mutants.

      (Littleton et al., 2001)

      sytAD1/sytT41 transheterozygotes survive until eclosion. The frequency of immature filopodial contacts on muscle fibres 6 and 7 ("collateral sprouts") in sytAD1/sytT41 embryos is similar to wild-type.

      (Jarecki and Keshishian, 1995)

      No obvious morphological defects.

      (Littleton and Bellen, 1994)

      Transheterozygote combinations with other syt alleles are lethal.

      (Littleton et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Isolated on basis of failure to complement Df(2L)DTD2.

      (Littleton et al., 1993)

      Mutant phenotype cannot be rescued when homozygous but can when in trans to sytN6 by sytelav.PD.

      (Littleton et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Syt1T41
      (Poskanzer et al., 2006)
      sytT41
      Name Synonyms
      Secondary FlyBase IDs
        References (6)