FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Syt1T77
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General Information
Symbol
Dmel\Syt1T77
Species
D. melanogaster
Name
FlyBase ID
FBal0032853
Feature type
allele
Associated gene
Dmel\Syt1
Associated Insertion(s)
P{lacW}Syt1T77
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Littleton et al., 1994, Littleton et al., 1993)
Mutagen
Delta2-3 transposase
(Littleton and Bellen, 1994, Littleton et al., 1994, Littleton et al., 1993)
P-element activity
(Littleton et al., 1995)
Progenitor genotype
P{lacW}B8-2-30
(Littleton and Bellen, 1994, Littleton et al., 1993)
Associated Insertion(s)
P{lacW}Syt1T77
Cytology
Description

Insertion of a P{lacW} element upstream of the putative transcription start site.

(Littleton et al., 1995)

Insertion of P{w+,lacZ} 250bp 5' of the longest syt cDNA analysed.

(Littleton et al., 1993)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Germ-line clones of this mutant often produce miniature eggs with greatly reduced surface volumes.

      (Ruden et al., 2000)

      No obvious morphological defects.

      (Littleton and Bellen, 1994)

      Transheterozygote combinations with other syt alleles are lethal.

      (Littleton et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Syt1k05909

      (Stefancsik, 2002.5.22)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      This allele isolated by local hopping of P element in P{w+,lacZ}B8 (at most 10kb from 3' end of syt transcript) into syt, and detected with PCR. Precise excision of element in sytT77 reverts lethality. A few adults survive in transheterozygous combinations between sytT11, sytT77 and syt66.4.

      (Littleton et al., 1993)

      Mutant phenotype can be rescued, when homozygous or in trans to sytN6, by sytelav.PD.

      (Littleton et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Syt1T77
      syt1T77
      (Tsarouhas et al., 2023)
      sytT77
      sytT77
      (Kang et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)