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General Information
Symbol
Dmel\Ca-α1DX7
Species
D. melanogaster
Name
FlyBase ID
FBal0033486
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ca-α1DX7 mutant males, but not females, show a significantly increased lifespan and a less severe age-dependent decline in locomotion, as compared to controls.

Ca-α1DX7 mutants show decreased cardiac function, as shown by the significant decrease in fractional shortening, but not in heart rate, end diastolic diameter, end systolic diameter or arrhythmic index, as compared to controls.

Mutants die at the late embryonic stage with no gross morphological abnormalities. The tracheae of mutant embryos generally do not become gas-filled. Embryos do move but the movements are very weak: slow localised twitches, usually at the posterior end. Some peristaltic motion is visible in the gut, this is very slow. Occasionally embryos bend their heads but movement of the cephalopharyngeal apparatus is not seen. Pumping of the heart is not seen.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Ca-α1DX7/Ca-alpha1D[+] is a suppressor | partially of lethal phenotype of Cam7/Camn339

Phenotype Manifest In
Suppressor of
Statement
Reference

Ca-α1DX7/Ca-alpha1D[+] is a suppressor | partially of pupa phenotype of Cam7/Camn339

Other
Statement
Reference

Ca-α1DX7/Ca-alpha1D[+], Cam7/Camn339 has wing phenotype

Additional Comments
Genetic Interactions
Statement
Reference

Ca-α1DX7/+ has a slight suppressing effect on the Cam7/Camn339 phenotype; there is a small but significant increase in the pupal length:width ratio, but no obvious effect on pupal case indentations, and a small fraction of the animals eclose as weak, uncoordinated adults with no wing expansion.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

S. Roth.

Comments
Comments

Shows normal GABA staining in stage 17 nerve cord.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Ca-α1DX7
Name Synonyms
Secondary FlyBase IDs
    References (7)