FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ptcConf-1
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General Information
Symbol
Dmel\ptcConf-1
Species
D. melanogaster
Name
FlyBase ID
FBal0033514
Feature type
allele
Associated gene
Dmel\ptc
Associated Insertion(s)
Carried in Construct
Also Known As
ptcCon, Confused
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: W236R.

    (Mullor and Guerrero, 2000)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2R:8,660,865..8,660,865 [+]
    Nucleotide change:

    T8660865M

    Amino acid change:

    W236R | ptc-PA

    Reported amino acid change:

    W236R

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Mullor and Guerrero, 2000)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygotes show an increased number of campaniform sensilla along wing vein 3 compared to wild type.

        (Ayers et al., 2009)

        In ptcConf-1/+ wings, the distance between veins 3 and 4 are slightly reduced. The wing margin bristles between these veins are transformed to anterior bristles of the double row. eyes are reduced in size, ocellar and scutellar bristles are reduced in number. Homozygotes die as third instar larvae, and form small imaginal discs. In ptctuf-1/ptcConf-1 flies the development of the central region of the wing is affected, vein 4 partially develops, and vein 3 is thickened. Homozygous ptcConf-1 clones in the wing differentiate vein 3 when close to the posterior compartment and substitute vein 4 for vein 3. Clones close to but not touching the anterior posterior border do not develop vein 3.

        (Mullor and Guerrero, 2000)

        fu-like phenotype, interacts with cos and "Cos".

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        ptcConf-1 has lethal phenotype, suppressible by Scer\GAL4C-765/dppUAS.cCa

        (Mullor and Guerrero, 2000)

        ptcConf-1 has lethal phenotype, suppressible by Su(fu)LP

        (Mullor and Guerrero, 2000)

        ptcConf-1 has lethal phenotype, suppressible by Scer\GAL4C-765/smoUAS.cMa

        (Mullor and Guerrero, 2000)
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        ptcConf-1 has phenotype, enhanceable by smoEW2

        (Hooper, 2013.5.30)

        ptcConf-1 has campaniform sensillum of dorsal radius phenotype, enhanceable by tow754/tow754

        (Ayers et al., 2009)
        Suppressed by
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The number of campaniform sensilla along wing vein 3 is dramatically increased when ptcConf-1/+ is placed in a tow754/tow754 background.

        (Ayers et al., 2009)

        The addition of smoScer\UAS.cMa driven by Scer\GAL4C-765 completely rescues the ptcConf-1 phenotypes. The addition of dppScer\UAS.cCa driven by Scer\GAL4C-765 rescues the lethality phenotype associated with ptcConf-1 and partially rescues the wing phenotype - Normal patterning is seen, except in the central region of the wing where only vein 3 develops. The addition of Su(fu)LP driven by Scer\GAL4C-765 partially rescues the ptcConf-1 phenotypes. the lethality is rescued, and the wing develops normally except for occasional costa supplications.

        (Mullor and Guerrero, 2000)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Complements

        ptcS2

        (Martin et al., 2001)
        Partially complements

        ptctuf-1

        (Mullor and Guerrero, 2000)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer

        Bruce Reed.

        Comments
        Comments

        Might be amos allele. Maps to amos interval (Joan Hooper).

        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (5)
        Reported As
        Symbol Synonym
        Conf1
        ptcCon
        (Ayers et al., 2009, Martin et al., 2001, Mullor and Guerrero, 2000)
        ptcConf-1
        (Hooper, 2013.5.30)
        ptc[Con]
        (Badrinath et al., 2006)
        Name Synonyms
        Confused
        (Ayers et al., 2009, Mullor and Guerrero, 2000)
        Secondary FlyBase IDs
          References (5)