FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dscam11
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General Information
Symbol
Dmel\Dscam11
Species
D. melanogaster
Name
FlyBase ID
FBal0035028
Feature type
allele
Associated gene
Dmel\Dscam1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Alavi et al., 2016)
Mutagen
ethyl methanesulfonate
(Roote, 1995.9.26, Heitzler et al., 1993)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dscam11 homozygous and Dscam11/Dscam105518 transheterozygous embryonic heart cardioblasts show significant decreases in migration velocity and in filopodial and lamellopodial activities, as compared to controls. Dscam11 heterozygous embryonic heart cardioblasts also show a significant decrease in filopodial activity, but not in lamellopodial activity or migration velocity, as compared to controls.

      (Raza and Jacobs, 2016)

      Dscam1 hemizygous mutants exhibit mild to severe disorganisation of embryonic axon tracts. Breaks in the connectives, predominantly of the outer two fascicles are observed. In addition axon bundles aberrantly cross the midline. Some 53%-58% of Bolwig's nerve (BN) projections are defective in Dscam1 hemizygotes. In half of the "abnormal projections" the entire nerve mistargets, whereas in the remainder only a subset of axons does. Many otherwise normal projections show abnormal expansion of BN terminus at P2.

      (Schmucker et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Dscam105518/Dscam11 has abnormal cell migration | embryonic stage phenotype, non-enhanceable by fra3/fra[+]

      (Raza and Jacobs, 2016)

      Dscam105518/Dscam11 has abnormal cell migration | embryonic stage phenotype, non-enhanceable by robo11/robo1[+]

      (Raza and Jacobs, 2016)
      Suppressor of
      Statement
      Reference

      Dscam1[+]/Dscam11 is a suppressor of abnormal cell migration | dominant | embryonic stage phenotype of robo11

      (Raza and Jacobs, 2016)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Dscam105518/Dscam11 has lamellipodium | embryonic stage phenotype, enhanceable by fra3/fra[+]

      (Raza and Jacobs, 2016)

      Dscam105518/Dscam11 has embryonic heart cardioblast phenotype, enhanceable by fra3/fra[+]

      (Raza and Jacobs, 2016)

      Dscam105518/Dscam11 has filopodium | embryonic stage phenotype, enhanceable by robo11/robo1[+]

      (Raza and Jacobs, 2016)

      Dscam105518/Dscam11 has lamellipodium | embryonic stage phenotype, enhanceable by robo11/robo1[+]

      (Raza and Jacobs, 2016)

      Dscam105518/Dscam11 has embryonic heart cardioblast phenotype, enhanceable by robo11/robo1[+]

      (Raza and Jacobs, 2016)

      Dscam11 has embryonic heart cardioblast | embryonic stage phenotype, enhanceable by robo11/robo1[+]

      (Raza and Jacobs, 2016)

      Dscam11 has filopodium | embryonic stage phenotype, enhanceable by robo11/robo1[+]

      (Raza and Jacobs, 2016)

      Dscam11 has embryonic heart cardioblast | embryonic stage phenotype, enhanceable by fra3/fra[+]

      (Raza and Jacobs, 2016)

      Dscam11 has filopodium | embryonic stage phenotype, enhanceable by fra3/fra[+]

      (Raza and Jacobs, 2016)

      Dscam105518/Dscam11 has filopodium | embryonic stage phenotype, enhanceable by fra3/fra[+]

      (Raza and Jacobs, 2016)
      Suppressed by
      Statement
      Reference

      Dscam11 has embryonic heart cardioblast | embryonic stage phenotype, suppressible by robo11/robo1[+]

      (Raza and Jacobs, 2016)
      Enhancer of
      Statement
      Reference

      Dscam1[+]/Dscam11 is an enhancer of embryonic heart cardioblast | embryonic stage phenotype of robo11

      (Raza and Jacobs, 2016)

      Dscam1[+]/Dscam11 is an enhancer of filopodium | embryonic stage phenotype of robo11

      (Raza and Jacobs, 2016)

      Dscam1[+]/Dscam11 is an enhancer of lamellipodium | embryonic stage phenotype of robo11

      (Raza and Jacobs, 2016)

      Dscam1[+]/Dscam11 is an enhancer of embryonic heart cardioblast phenotype of fra3

      (Raza and Jacobs, 2016)

      Dscam1[+]/Dscam11 is an enhancer of filopodium | embryonic stage phenotype of fra3

      (Raza and Jacobs, 2016)
      Suppressor of
      Statement
      Reference

      Dscam1[+]/Dscam11 is a suppressor of embryonic heart cardioblast | embryonic stage phenotype of robo11

      (Raza and Jacobs, 2016)
      Other
      Statement
      Reference

      Dscam1[+]/Dscam11, fra3 has embryonic heart cardioblast phenotype

      (Raza and Jacobs, 2016)

      Dscam1[+]/Dscam11, fra3 has lamellipodium | embryonic stage phenotype

      (Raza and Jacobs, 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dscam11, robo11 double heterozygotes show a more severe decrease in filopodial activity compared to either single heterozygote conditions, a more severe decrease in lamellopodial activity compared to robo11 heterozygotes, and no migration velocity defects compared to wild-type controls. Dscam11, fra3 double heterozygotes show a severe decrease in lamellopodial activity compared to wild-type controls and a more severe decrease in filopodial activity compared to either single heterozygote conditions, but do not show significant changes in migration velocity compared to wild-type controls.

      The decreased filopodial and lamellopodial activities, but not the decreased migration velocity, observed in Dscam11/Dscam105518 transheterozygous embryonic heart cardioblasts are enhanced by either robo11 or fra3 heterozygosity.

      (Raza and Jacobs, 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Dscam11
      (Liu et al., 2024, Kang et al., 2019, Alavi et al., 2016)
      Dscam1
      (Shin and Diantonio, 2011)
      DscamE1
      (Schmucker et al., 2000)
      Ew2
      (Roote, 1995.9.26)
      dscam11
      (Raza and Jacobs, 2016)
      l(2)43Bc1
      (Roote, 1999.3.10, Heitzler et al., 1993)
      Name Synonyms
      Secondary FlyBase IDs
        References (11)