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General Information
Symbol
Dmel\sliE-158
Species
D. melanogaster
Name
FlyBase ID
FBal0035623
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sliE158, slitE158, slitE-158
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P-element insert 500bp 5' to the start of translation.

P{lArB} insertion 105bp upstream of the coding region and transcription initiation sequence.

Insertion components
P{lArB}sliE-158
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

sliE-158 homozygous embryos exhibit severe axon guidance defects in the longitudinal connective from 14h post-fertilization onwards, as compared to controls.

Medial longitudinal tracts are seen to cross the midline in 14 hour mutant embryos.

slik04807b/sliE-158 third instar larvae show defects in photoreceptor axon targeting, with gaps in the lamina and increased numbers of axons entering the medulla.

3.1% of expected mutant embryos hatch as first instar larvae. The latest observed stage of mutants is pupa. Nerve cord length is 82% of embryo length. Midline guidance failure of repellence phenotype, evidenced by midline crossing, is mild.

Embryos show a partial midline collapse of the central nervous system.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

sliE-158 has larval ventral nerve cord phenotype, enhanceable by robo[+]/robo11

sliE-158 has larval longitudinal connective phenotype, enhanceable by robo[+]/robo11

NOT Enhanced by
Statement
Reference
Enhancer of
Statement
Reference

sli[+]/sliE-158 is an enhancer of larval longitudinal connective phenotype of robo11

Additional Comments
Genetic Interactions
Statement
Reference

The longitudinal tracts of embryos expressing NetBScer\UAS.cHa under the control of Scer\GAL4unspecified in a sliE-158 background appear similar to those seen in strong loss-of-function sli mutant embryos. Expression of fraScer\UAS.cKa under the control of Scer\GAL4elav.PLu does not enhance the sliE-158 longitudinal tract phenotype.

Percentage of segments with midline crossovers in robo1/sliE-158 transheterozygotes is 35%.

Embryos heterozygous for both robo1 and sliE-158 show deviation of longitudinal fascicles towards the midline in 32% of segments.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)