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Citation
Kidd, T., Bland, K.S., Goodman, C.S. (1999). Slit is the midline repellent for the robo receptor in Drosophila.  Cell 96(6): 785--794.
FlyBase ID
FBrf0107807
Publication Type
Research paper
Abstract

Previous studies suggested that Roundabout (Robo) is a repulsive guidance receptor on growth cones that binds to an unknown midline ligand. Here we present genetic evidence that Slit is the midline Robo ligand; a companion paper presents biochemical evidence that Slit binds Robo. Slit is a large extracellular matrix protein expressed by midline glia. In slit mutants, growth cones enter the midline but never leave it; they abnormally continue to express high levels of Robo while at the midline. slit and robo display dosage-sensitive genetic interactions, indicating that they function in the same pathway. slit is also required for migration of muscle precursors away from the midline. Slit appears to function as a short-range repellent controlling axon crossing of the midline and as a long-range chemorepellent controlling mesoderm migration away from the midline.

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Review

Paper alert.
Anonymous, 1999, Curr. Opin. Neurobiol. 9(3): 253 [FBrf0112212]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Alleles (15)
    Genes (9)
    Insertions (3)
    Experimental Tools (1)
    Transgenic Constructs (5)