FlyBase Allele Report: Dmel\Ten-m[00844]

General Information

Symbol

Dmel\Ten-m⁰⁰⁸⁴⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0039083

Feature type

allele

Associated gene

Dmel\Ten-m

Associated Insertion(s)

P{PZ}Ten-m⁰⁰⁸⁴⁴

Carried in Construct

Also Known As

odz^l(3)844, l(3)844, Penh21

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Baumgartner et al., 1994)

Progenitor genotype

Associated Insertion(s)

P{PZ}Ten-m⁰⁰⁸⁴⁴

Cytology

Description

Insertion at nucleotide 4259 within exon 1.

(Levine et al., 1997)

Insertion in 5' non-coding region of the transcript.

(Levine et al., 1994)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

AF008224

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(Baumgartner et al., 1994)

some die during embryonic stage

(Baumgartner et al., 1994)

Phenotype Manifest In

Detailed Description

Statement

Reference

No defects in cuticle pattern.

(Baumgartner et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

Df(1)KA6/+, Ten-m⁰⁰⁸⁴⁴ has ommatidium phenotype

(Kinel-Tahan et al., 2007)

Df(1)KA6/+, Ten-m⁰⁰⁸⁴⁴ has interommatidial bristle phenotype

(Kinel-Tahan et al., 2007)

Df(1)KA6/+, Ten-m⁰⁰⁸⁴⁴ has interommatidial bristle | increased number phenotype

(Kinel-Tahan et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Df(1)KA6; Ten-m⁰⁰⁸⁴⁴ double heterozygotes display interommatidial bristle loss, supernumerary interommatidial bristles, uneven ommatidial size and shape, column disorder, and interommatidial fusions in 21-30% of adults.

(Kinel-Tahan et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Ten-m⁰⁵³⁰⁹

(BDGP Project Members, 1994-1999)

Ten-m⁰⁰⁸⁷⁶

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Complements: l(3)00506⁰⁰⁵⁰⁶.

(BDGP Project Members, 1994-1999)

FlyBase curator comment: FBrf0214744 characterises new loss of function mutations in Ten-m and finds no evidence of a pair-rule segmentation phenotype, in contrast to previous reports. The authors show that the pair-rule phenotype previously reported for a number of Ten-m mutations (Ten-m⁰⁵³⁰⁹, Df(3L)Ten-m-AL1 and Df(3L)Ten-m-AL29) was in fact due to a mutation present on the balancer in the original stock. The segmentation phenotype described in FBrf0201077, FBrf0073721, FBrf0098973 and FBrf0204395 for Ten-m⁰⁰⁸⁴⁴ has thus been removed from the allele report in FlyBase, since it is likely that this phenotype is due to a second-site mutation rather than the mutation in Ten-m.

(FlyBase, 1992-)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AF008224

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Penh21

(Levine et al., 1997, Levine et al., 1994)

Ten-m⁰⁰⁸⁴⁴

l(3)00844⁰⁰⁸⁴⁴

l(3)844

(Rakovitsky et al., 2007, Levine et al., 1994)

odz⁸⁴⁴

(Rakovitsky et al., 2007)

odz^l(3)488

(Kinel-Tahan et al., 2007)

odz^l(3)844

(Kinel-Tahan et al., 2007, Rakovitsky et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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