FlyBase Allele Report: Dmel\bs[11]

General Information

Symbol

Dmel\bs¹¹

Species

D. melanogaster

Name

FlyBase ID

FBal0039182

Feature type

allele

Associated gene

Dmel\bs

Associated Insertion(s)

Carried in Construct

Also Known As

bs^F61

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Fristrom et al., 1994)

Progenitor genotype

Cytology

Description

Amino acid replacement: G204E. Mutation falls within the MADS-box and is conserved in all vertebrate SRF and yeast orthologs. This glycine is centered in a tight turn joining an alpha helix (αI) involved in DNA binding and a beta strand (βI) required for dimerization. Nucleotide substitution: a GGG codon is replaced by a GAG.

(Montagne et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:24,348,237..24,348,237 [+]

Nucleotide change:

G24348237A

Reported nucleotide change:

G?A

Amino acid change:

G204E | bs-PA; G204E | bs-PB; G204E | bs-PC

Reported amino acid change:

G204E

(Montagne et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive

(Montagne et al., 1996, Fristrom et al., 1994)

Phenotype Manifest In

submarginal wing cell

(Fristrom et al., 1994)

wing

(Murray et al., 1995, Fristrom et al., 1994)

wing disc | P-stage (with In(2LR)Px⁴)

(Fristrom et al., 1994)

wing vein

(Montagne et al., 1996, Murray et al., 1995, Sturtevant and Bier, 1995)

wing vein | ectopic

(Fristrom et al., 1994)

Detailed Description

Statement

Reference

Many additional wing veins.

(Montagne et al., 1996)

Large blisters on the wing and enlarged veins where the dorsal and ventral remain apart.

(Murray et al., 1995)

Extra vein mutation.

(Sturtevant and Bier, 1995)

Wings are blistered and show ectopic, wide veins. 2 hours after puparium formation defects in wing discs of bs¹¹/In(2LR)Px⁴ become apparent. The distal and anterior submarginal cells detach from the larval basal lamina but do not become closely apposed, leaving an empty space. In the central region the apposed basal surfaces are often in close proximity but do not make contact and form junctions. bs¹¹ homozygotes have abnormally wide, laminin-lined, prevein lacunae alternate with narrow stretches where dorsal and ventral surfaces have adhered.

(Fristrom et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

bs¹¹ is an enhancer of wing vein | ectopic phenotype of rho^hs.PSt

(Sturtevant and Bier, 1995)

Suppressor of

Statement

Reference

bs¹¹ is a suppressor of wing vein phenotype of rho^ve-1

(Sturtevant and Bier, 1995)

Other

Statement

Reference

bs¹¹, rho^ve-1 has wing vein L2 phenotype

(Fristrom et al., 1994)

bs¹¹, rho^ve-1 has wing vein L5 phenotype

(Fristrom et al., 1994)

bs¹¹, rho^ve-1 has wing vein L3 phenotype

(Fristrom et al., 1994)

bs¹¹, rho^ve-1 has wing vein L4 phenotype

(Fristrom et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Enhancement of rho^hs.PSt ectopic vein phenotype and suppression of the rho^ve-1 loss of vein phenotype.

(Sturtevant and Bier, 1995)

rho^ve-1 suppresses the bs¹¹ vein defects although L2 to L5 remain truncated distally.

(Fristrom et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Alleles fall into a series in ascending order of severity: bs^A48 < bs¹¹ < bs¹² < bs¹³ < bs¹⁴ < Df(2R)bs-F31.

(Fristrom et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

bs¹¹

bs^F61

(Murray et al., 1995, Sturtevant and Bier, 1995)

l(2)F61

Name Synonyms

Secondary FlyBase IDs

References (4)

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