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General Information
Symbol
Dmel\phocv
Species
D. melanogaster
Name
FlyBase ID
FBal0039759
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    As for phoc : 7.5kb gypsy insertion within an 86bp intron in the 5' non-coding region of the transcript. Presumably a second lesion has occurred, and is responsible for the altered behavior of phocv.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Maternal effect phocv/phocv embryos raised at the restrictive temperature of 25[o]C show transformation of the denticle belts of thoracic segments to the first abdominal segments and the posterior abdominal segments to the eighth segment.

    Embryos display incomplete head involution with the appearance of extra copies of anterior structures. Homeotic transformation of the thoracic segments to a more posterior identity, but not beyond the first abdominal segment. Homeotic transformation of abdominal segments 6 and 7 to the identity of the eighth. Strong effect on the overall organisation and development of the CNS and PNS. A small fraction survive to larval hatching and adulthood. Some males have small darkly pigmented patches of cuticle in the fourth abdominal segment, a partial transformation of the fourth segment to a more posterior segment.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Suppressed by
    Statement
    Reference
    NOT suppressed by
    Statement
    Reference

    phocv/pho1 has antenna phenotype, non-suppressible by Hsap\YY1arm.PA

    phocv/pho1 has sex comb phenotype, non-suppressible by Hsap\YY1arm.PA

    phocv/pho1 has unguis phenotype, non-suppressible by Hsap\YY1arm.PA

    Suppressor of
    Statement
    Reference

    phocv is a suppressor of phenotype of wiab-2(1.7)

    phocv is a suppressor of phenotype of w4.Ubx.bxd:pbx.ΔBC3-PHO1-2

    phocv is a suppressor of phenotype of w4.Ubx.bxd:pbx.ΔBC3-PHO2

    phocv is a suppressor of phenotype of wen.8

    NOT Suppressor of
    Statement
    Reference

    phocv is a non-suppressor of phenotype of w4.Ubx.bxd:pbx.ΔBC3-PHO1

    Other
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    pho1/phocv suppresses the pairing-dependent silencing of wiab-7PRE.860 seen in flies homozygous for P{iab-7PRE-w.860}P24.

    The addition of homozygous phocv reduces the pairing sensitive suppression of w gene expression seen in homozygous wiab-2(1.7) flies.

    The addition of pho1/phocv strongly suppresses the Pairing sensitive silencing effect seen in wMcp.10, wMcp.13,wMcp.scs'.12:15 and wMcp.scs'.11. the addition of pho1/phocv has no effect on the Pairing sensitive silencing effect seen in wMcp.11, and wMcp.scs'.14. The addition pho1/phocv very strongly suppresses the Pairing sensitive silencing effect seen in the wMcp.scs'.14/ wMcp.13 (P{Mcp-w#14}AP-2stummelbein/+, P{Mcp-w#13}116/+) double heterozygous insertion.

    Eye colour encoded by wen.8 is darker in pho1/pho1 or pho1/phocv background.

    Xenogenetic Interactions
    Statement
    Reference

    When heatshocked twice daily, Hsap\YY1Hsp70.T:Scer\GAL4 nearly completely corrects the antennal and sex comb defects in pho1/phocv mutant flies. Segmentation is largely normal, although pigmentation on tergite 5 is not always complete. Correction of claw structures is variable ranging from complete to partial correction.

    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    Comments
    Comments

    Homozygotes die before pharate adult stage and hemizygotes survive with a weak pho phenotype. This suggests lethality could be due to a second site lethal. Recombinants were isolated, one gave a homozygous viable pho phenotype, the pho allele is referred to as phocv, it is not known if this is a partial revertant of phoc or removal of the second site lethal.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (11)