FlyBase Allele Report: Dmel\snf[J210]

General Information

Symbol

Dmel\snf^J210

Species

D. melanogaster

Name

FlyBase ID

FBal0039929

Feature type

allele

Associated gene

Dmel\snf

Associated Insertion(s)

Carried in Construct

Also Known As

snf²¹⁰

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Nagengast et al., 2003, Flickinger and Salz, 1994)

Mutagen

Delta2-3 transposase

(Flickinger and Salz, 1994)

Progenitor genotype

Df(1)PR110

(Flickinger and Salz, 1994)

Caused by aberration

Df(1)J210

Cytology

Description

Small deletion of the entire open reading frame starting in the 5' untranslated region and extending into the adjacent gene, dhd.

(Salz and Flickinger, 1996)

Deletion that removes the P{lacW} insertion of Df(1)PR110 and extends to nucleotide 21 of the 5' untranslated region of snf.

(Flickinger and Salz, 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Hsieh et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Nagengast and Salz, 2001)

lethal | recessive

(Nagengast et al., 2003)

lethal - all die during embryonic stage | recessive

(Salz and Flickinger, 1996, Flickinger and Salz, 1994)

some die during embryonic stage | recessive

(Salz and Flickinger, 1996, Flickinger and Salz, 1994)

Phenotype Manifest In

prothoracic leg & macrochaeta | female

(Salz and Flickinger, 1996)

Detailed Description

Statement

Reference

snf^J210/+ heterozygous 5 day old adults do not have any alterations in electroretinogram amplitude, compared to controls.

(Hsieh et al., 2019)

Sxl^Mf1/Y males with a single extra copy of P{snf⁺,dhd⁺}, are considerably more masculine after the addition of Df(1)J210 (which contains snf^J210).

(Cline et al., 1999)

Embryos develop until stage 14. Mitotic clones induced during second instar larval period that fall within the sexually dimorphic region of the female foreleg contain intermediate sexual bristles. Clones induced during third larval instar fail to show signs of sexual transformation. No clones induced during first larval instar are recovered in the foreleg. Male hemizygous embryos complete embryogenesis without any gross developmental abnormalities as maternally provided snf is at near normal levels throughout embryogenesis.

(Salz and Flickinger, 1996)

Heterozygotes with snf^JA2 and snf¹ (both in the presence of the transgene P{dhd4.8}) produce ovarian tumours. Weak lethal synergistic interaction with Sxl, only detectable with homozygous mothers.

(Flickinger and Salz, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by da[+]/da²

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by Df(2R)Su(z)3-1.iy/+

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | maternal effect | female phenotype, enhanceable by AspRS^25-1R/AspRS[+]

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | maternal effect | female phenotype, enhanceable by TrpRS[+]/TrpRS⁰³⁵⁵⁹

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | maternal effect | female phenotype, enhanceable by TrpRS[+]/TrpRS⁴⁴²⁰

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | maternal effect | female phenotype, enhanceable by TrpRS[+]/TrpRS^P-74

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | maternal effect | female phenotype, enhanceable by TrpRS^P-28B/TrpRS[+]

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by Df(3R)by10/+

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | maternal effect | female phenotype, enhanceable by AspRS^TW6/AspRS[+]

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | maternal effect | female phenotype, enhanceable by AspRS^TW3/AspRS[+]

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | maternal effect | female phenotype, enhanceable by AspRS^12-21R/AspRS[+]

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | maternal effect | female phenotype, enhanceable by AspRS¹/AspRS[+]

(Stitzinger et al., 1999)

NOT suppressed by

Statement

Reference

snf^J210 has lethal phenotype, non-suppressible by dhd^+t4.8

(Flickinger and Salz, 1994)

Enhancer of

Statement

Reference

snf[+]/snf^J210 is an enhancer of abnormal neurophysiology | adult stage phenotype of Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

Suppressor of

Statement

Reference

snf[+]/snf^J210 is a suppressor of lethal | female phenotype of Sxl^fP7B0

(Stitzinger et al., 1999)

NOT Suppressor of

Statement

Reference

snf[+], da[+], snf^J210, da² is a non-suppressor of lethal | female phenotype of Sxl^fP7B0

(Stitzinger et al., 1999)

Other

Statement

Reference

Sxl^fP7B0, snRNP-U1-70K⁰²¹⁰⁷, snf^J210 has lethal phenotype

(Nagengast et al., 2003)

Sxl^fP7B0, U2af38^ΔE18, snf^J210 has lethal phenotype

(Nagengast et al., 2003)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female phenotype

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype

(Stitzinger et al., 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

snf[+]/snf^J210 is an enhancer of retina phenotype of Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

NOT Enhancer of

Statement

Reference

snf[+]/snf^J210 is a non-enhancer of adult brain phenotype of Hsap\MAPT^{R406W.UAS.cUa}, Scer\GAL4^elav-C155

(Hsieh et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

The female progeny of snf^J210/+ females mated to Sxl^fP7B0/Y males show only 83.6% viability.

The female progeny of snf^J210/+ ; fl(2)d¹/+ females mated to Sxl^fP7B0/Y males show only 27.6% viability.

The female progeny of snf^J210/+ ; fl(2)d²/+ females mated to Sxl^fP7B0/Y males show only 74.4% viability.

The female progeny of snf^J210/+ ; snf^5MER females mated to Sxl^fP7B0/Y males show 98% viability.

The female progeny of snf^J210/+ ; fl(2)d¹/+ ; snf^5MER females mated to Sxl^fP7B0/Y males show 16.1% viability.

The female progeny of snf^J210/+ ; fl(2)d²/+ ; snf^5MER females mated to Sxl^fP7B0/Y males show 79.3% viability.

(Penn et al., 2008)

When mothers heterozygous for both snf^J210 and snRNP70K⁰²¹⁰⁷ are crossed with Sxl^fP7B0 males, a significant reduction in viability is seen in Sxl^fP7B0/+ daughters. When mothers heterozygous for both snf^J210 and U2af38^ΔE18 are crossed with Sxl^fP7B0 males, a significant reduction in viability is seen in Sxl^fP7B0/+ daughters. When mothers heterozygous for both snf^J210 and U2af50^XR15 are crossed with Sxl^fP7B0 males, no significant reduction in viability is seen in Sxl^fP7B0/+ daughters.

(Nagengast et al., 2003)

Female Sxl^fP7B0/+ embryos are 80% viable if their mothers are heterozygous for snf^J210, but only 7% viable if their mothers are heterozygous for both da² and snf^J210. The weak interaction between Sxl^fP7B0 and snf^J210 is enhanced by Df(2R)Su(z)3-1.iy, Aats-asp^TW6, Aats-asp^TW3, Aats-asp^12-21R, Aats-asp¹ or Aats-asp^25-1R; the viability of female Sxl^fP7B0/+ embryos derived from mothers heterozygous for snf^J210 and one of Df(2R)Su(z)3-1.iy, Aats-asp^TW6, Aats-asp^TW3, Aats-asp^12-21R, Aats-asp¹ or Aats-asp^25-1R is reduced. The weak interaction between Sxl^fP7B0 and snf^J210 is enhanced by Aats-trp⁰³⁵⁵⁹, Aats-trp⁴⁴²⁰, Aats-trp^P-74, Aats-trp^P-28B or Df(3R)by10; the viability of female Sxl^fP7B0/+ embryos derived from mothers heterozygous for snf^J210 and one of Aats-trp⁰³⁵⁵⁹, Aats-trp⁴⁴²⁰, Aats-trp^P-74, Aats-trp^P-28B or Df(3R)by10 is reduced.

(Stitzinger et al., 1999)

Weak dominant female lethal-synergistic interaction with Sxl^f1.

(Salz and Flickinger, 1996)

Lethality cannot be rescued by dhd^+t4.8.

(Flickinger and Salz, 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

snf^J210 is rescued by snf^ΔKPN

(Nagengast and Salz, 2001)

snf^J210 is rescued by snf^E21D+ΔKPN

(Nagengast and Salz, 2001)

snf^J210 is rescued by snf^+t5.5

(Larochelle et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

snf²¹⁰

(Hsieh et al., 2019, Hager and Cline, 1997)

snf^J210

(Penn et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (10)

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