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General Information
Symbol
Dmel\CycA04335
Species
D. melanogaster
Name
FlyBase ID
FBal0042464
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{PZ}CycA04335
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In mutant embryos the division of neurons are affected in a lineage specific manner. The ganglion mother cell (GMC) of the RP2/sib lineage fails to divide, and assumes the identity of the RP2 neuron. The GMC of the aCC/pCC lineage is similarly affected; it fails to divide and assumes the identity of the aCC. These phenotypes are fully penetrant. Timing and axonal projections from these neurons continue as if they were wildtype. Other lineages are also affected in mutant embryos. The CQ lineage fails to divide in about 75% of hemisegments and the U lineage fails to divide in all hemisegments. The effect on the EL line is minimal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

CycA04335 is an enhancer of RP2 motor neuron phenotype of numb796

CycA04335 is an enhancer of aCC neuron | precursor phenotype of numb796

CycA04335 is an enhancer of pCC neuron | precursor phenotype of numb796

Additional Comments
Genetic Interactions
Statement
Reference

In about 35% of hemisegments in numb796; CycA04335 double mutants, the GMC of the RP2/sib lineage fails to divide, and assumes the identity of the sib neuron. However, the GMC of the aCC/pCC lineage fails to divide and assumes the identity of the aCC, as in CycA04335 mutants alone.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

A. Spradling.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
CycA04335
l(3) 03445
l(3)0433504335
Name Synonyms
Secondary FlyBase IDs
    References (3)