FlyBase Allele Report: Dmel\CycA[04335]

General Information

Symbol

Dmel\CycA⁰⁴³³⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0042464

Feature type

allele

Associated gene

Dmel\CycA

Associated Insertion(s)

P{PZ}CycA⁰⁴³³⁵

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}CycA⁰⁴³³⁵

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

ganglion mother cell GMC4-2a

(Wai et al., 1999)

larval DA1 motor neuron | precursor

(Wai et al., 1999)

pCC neuron

(Wai et al., 1999)

pCC neuron | precursor

(Wai et al., 1999)

RP2sib neuron

(Wai et al., 1999)

U neuron

(Wai et al., 1999)

Detailed Description

Statement

Reference

In mutant embryos the division of neurons are affected in a lineage specific manner. The ganglion mother cell (GMC) of the RP2/sib lineage fails to divide, and assumes the identity of the RP2 neuron. The GMC of the aCC/pCC lineage is similarly affected; it fails to divide and assumes the identity of the aCC. These phenotypes are fully penetrant. Timing and axonal projections from these neurons continue as if they were wildtype. Other lineages are also affected in mutant embryos. The CQ lineage fails to divide in about 75% of hemisegments and the U lineage fails to divide in all hemisegments. The effect on the EL line is minimal.

(Wai et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

CycA⁰⁴³³⁵ is an enhancer of ganglion mother cell GMC4-2a phenotype of numb⁷⁹⁶

(Wai et al., 1999)

CycA⁰⁴³³⁵ is an enhancer of larval RP2 motor neuron phenotype of numb⁷⁹⁶

(Wai et al., 1999)

CycA⁰⁴³³⁵ is an enhancer of larval DA1 motor neuron | precursor phenotype of numb⁷⁹⁶

(Wai et al., 1999)

CycA⁰⁴³³⁵ is an enhancer of pCC neuron | precursor phenotype of numb⁷⁹⁶

(Wai et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

In about 35% of hemisegments in numb⁷⁹⁶; CycA⁰⁴³³⁵ double mutants, the GMC of the RP2/sib lineage fails to divide, and assumes the identity of the sib neuron. However, the GMC of the aCC/pCC lineage fails to divide and assumes the identity of the aCC, as in CycA⁰⁴³³⁵ mutants alone.

(Wai et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

CycA⁰³⁹⁴⁶

(BDGP Project Members, 1994-1999)

CycA^j3C8

(BDGP Project Members, 1994-1999)

CycA⁰¹⁵⁵⁸

(BDGP Project Members, 1994-1999)