FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mef2X1
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General Information
Symbol
Dmel\Mef2X1
Species
D. melanogaster
Name
FlyBase ID
FBal0042670
Feature type
allele
Associated gene
Dmel\Mef2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Bour et al., 1995)
Mutagen
X ray
(Bour et al., 1995)
Progenitor genotype
Caused by aberration
Df(2R)X1
Cytology
Description

Deficiency breakpoint breaks within the large intron that interrupts the 5' untranslated region of the Mef2 gene.

(Bour et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mef2X1/+ does not cause significant cardiac enlargement or reduced fractional shortening in adult hearts.

      (Lee et al., 2014)

      Embryonic lethal when heterozygous with Df(2R)520. Embryos exhibit lack of Mhc-expressing cells and lack of muscle fibres. Midgut morphogenesis and late heart differentiation are also defective.

      (Bour et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Mef2[+]/Mef2X1 is a suppressor of abnormal size | adult stage phenotype of Pp2B-14Dact.tin.C.Tag:FLAG

      (Lee et al., 2014)

      Mef2[+]/Mef2X1 is a suppressor of abnormal size | adult stage phenotype of Pp2B-14Dact.UAS.EYFP, Scer\GAL4tin.CΔ4

      (Lee et al., 2014)

      Mef2X1 is a suppressor of visible phenotype of Hsap\HTT128Q.1-336.UAS, Scer\GAL4GMR.PU

      (Kaltenbach et al., 2007)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Mef2[+]/Mef2X1 is a suppressor of adult heart phenotype of Pp2B-14Dact.tin.C.Tag:FLAG

      (Lee et al., 2014)

      Mef2[+]/Mef2X1 is a suppressor of adult heart phenotype of Pp2B-14Dact.UAS.EYFP, Scer\GAL4tin.CΔ4

      (Lee et al., 2014)

      Mef2X1 is a suppressor of eye phenotype of Hsap\HTT128Q.1-336.UAS, Scer\GAL4GMR.PU

      (Kaltenbach et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Mef2X1/+ rescues the cardiac enlargement and reduced fractional shortening phenotypes seen in flies expressing Pp2B-14Dact.tin.C.T:Zzzz\FLAG.

      Mef2X1/+ rescues the cardiac enlargement and the reduced fractional shortening phenotype of flies expressing Pp2B-14Dact.Scer\UAS.T:Avic\GFP-EYFP under the control of Scer\GAL4tin.CΔ4.

      (Lee et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (9)