FlyBase Allele Report: Dmel\emc[P5c]

General Information

Symbol

Dmel\emc^P5c

Species

D. melanogaster

Name

FlyBase ID

FBal0043020

Feature type

allele

Associated gene

Dmel\emc

Associated Insertion(s)

P{A92}emc^P5c

Carried in Construct

Also Known As

emc-lacZ

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Takahisa et al., 1996, Garrell and Modolell, 1990)

loss of function allele

(Cubas and Modolell, 1992)

Mutagen

P-element activity

(Heitzler et al., 1996, Cubas and Modolell, 1992, Garrell and Modolell, 1990, Romani et al., 1989)

Progenitor genotype

Associated Insertion(s)

P{A92}emc^P5c

Cytology

Description

P{A92} insertion 99 nucleotides upstream of the transcriptional start site.

(Heitzler et al., 1996)

Insertion of a P{A92} element into the promoter region.

(Cubas and Modolell, 1992)

Insertion of P-element (containing a Ecol\lacZ gene and a ry gene) into emc, at chromosomal locus 61C-61D, 99bp upstream of the origin of transcription.

(Garrell and Modolell, 1990)

Allele components

Component

Use(s)

Inserted element

P{A92}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:749,307..749,307

(Renaud and Simpson, 2002, Baonza and Garcia-Bellido, 1999, Heitzler et al., 1996, Cubas and Modolell, 1992, Garrell and Modolell, 1990, Romani et al., 1989)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

mesonotum

(Usui et al., 2008)

Additional Information

Statement

Reference

emc reporter expression is ubiquitous in the wing disc but two strong bands are seen in the anterior notum and in the area where the dorsocentral and postalar bristles will form. The domains of emc and h expression overlap in a band across the posterior notum. The emc and sr expression domains overlap in the anterior notum.

(Usui et al., 2008)

Marker for

Reflects expression of

emc

(Usui et al., 2008)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Garrell and Modolell, 1990)

Phenotype Manifest In

microchaeta & mesothoracic tergum | supernumerary

(Renaud and Simpson, 2002)

Detailed Description

Statement

Reference

emc^P5c animals have a higher density of notal microchaetae, however these bristles still approximately align into rows as seen in wild-type.

(Renaud and Simpson, 2002)

Flies doubly homozygous for emc^P5c and pyd^tam show a synergistic effect on the phenotype of emergence of extra bristles.

(Takahisa et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

emc^P5c has phenotype, enhanceable by bs⁰³²⁶⁷

(Roch et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

emc^P5C

(Foronda et al., 2012, Roch et al., 1998, Takahisa et al., 1996, Cubas and Modolell, 1992, Garrell and Modolell, 1990)

emc^P5c

extramacrochaete^P5C

(Renaud and Simpson, 2002)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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