FlyBase Allele Report: Dmel\Gdi[AF160]

General Information

Symbol

Dmel\Gdi^AF160

Species

D. melanogaster

Name

FlyBase ID

FBal0044839

Feature type

allele

Associated gene

Dmel\Gdi

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ricard et al., 2001)

Progenitor genotype

Cytology

Description

FlyBase curator comment: FBrf0139813 reports the amino acid change as G147term, but it's clear from the amino acid at position 147 and the reported nucleotide change that this is a mistake and should have been Q147term.

(Ricard et al., 2001)

Amino acid replacement: Q147term.

(Ricard et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:9,493,059..9,493,059 [-]

Nucleotide change:

C9493059T

Reported nucleotide change:

C?T

Amino acid change:

Q147term | Gdi-PA; Q147term | Gdi-PB; Q147term | Gdi-PC

Reported amino acid change:

?147term

Comment:

Though reported as G147term, it is apparent from the amino acid at position 147 (Gln, not Gly) and the nucleotide change information that it was meant to be Q147term.

(Ricard et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | recessive

(Ricard et al., 2001)

some die during larval stage | recessive

(Ricard et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

First instar larvae die shortly after hatching.

(Ricard et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Gdi^AF160, Scer\GAL4^arm.PS, rush^UAS.GFP has partially lethal - majority live phenotype, suppressible by sta^+t4.4/Df(1)rush⁴

(Gailite et al., 2012)

Other

Statement

Reference

Gdi^AF160, Scer\GAL4^arm.PS, rush^UAS.GFP has partially lethal - majority live phenotype

(Gailite et al., 2012)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Df(1)rush⁴, sta^+t4.4 does not affect survival of heterozygous Gdi^AF160 flies.

Scer\GAL4^arm.PS-mediated expression of rush^{Scer\UAS.T:Avic\GFP} decreases the viability of Gdi^AF160 heterozygotes. This effect is rescued in a Df(1)rush⁴, sta^+t4.4 background.

(Gailite et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Gdi^H1

(Mays et al., 2004)

Gdi^H4

(Mays et al., 2004)

Gdi^J1

(Mays et al., 2004)