FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Psch27
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General Information
Symbol
Dmel\Psch27
Species
D. melanogaster
Name
FlyBase ID
FBal0045018
Feature type
allele
Associated gene
Dmel\Psc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Wu and Howe, 1995)
Mutagen
ethyl methanesulfonate
(Wu and Howe, 1995)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
DQ022544
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      One copy of Psch27 is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)wm4.

      One copy of Psch27 is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

      (Doheny et al., 2008)

      Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosome.

      (Cryderman et al., 1999)

      Psch27/Psce24 embryos show a partial loss of ventral denticles.

      (Shao et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Psch27/Psc[+] is a suppressor of visible | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU

      (Morimoto et al., 2016)

      Psch27/Psc[+] is a suppressor of visible | adult stage phenotype of Hsap\SMARCAL1UAS.cBa, Scer\GAL4Bx-MS1096

      (Morimoto et al., 2016)
      Other
      Statement
      Reference

      Psch27, Su(z)21 has visible | dominant phenotype

      (Wu and Howe, 1995)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Psch27/Psc[+] is a suppressor of wing vein | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU

      (Morimoto et al., 2016)

      Psch27/Psc[+] is a suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1UAS.cBa, Scer\GAL4Bx-MS1096

      (Morimoto et al., 2016)
      Other
      Statement
      Reference

      Psch27, Su(z)21 has microchaeta phenotype

      (Wu and Howe, 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is ameliorated by combination with a single copy of Psch27.

      (Morimoto et al., 2016)

      Has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males.

      (McKee et al., 2000)

      Suppresses z1 eye color in a background of Su(z)24 or Su(z)31. Transheterozygotes with Su(z)21 show a subtle reduction in microchaetae.

      (Wu and Howe, 1995)
      Xenogenetic Interactions
      Statement
      Reference

      The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is ameliorated by combination with a single copy of Psch27.

      (Morimoto et al., 2016)
      Complementation and Rescue Data
      Partially rescued by

      Psch27 is partially rescued by PscTag:FLAG

      (Shao et al., 1999)
      Comments

      Psch27/Psce24 embryos rescued by one copy of P{Pc-Psc.FLAG} show rescued denticle belts and some hatch to larvae, though none reach adulthood.

      (Shao et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Member of the "hapless" class of Psc alleles, i.e. lethal in trans to other "hapless" alleles and deficiencies of the region.

      (Wu and Howe, 1995)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (1)
      References (15)