FlyBase Allele Report: Dmel\Ubx[1:Cbx-1]

General Information

Symbol

Dmel\Ubx^1:Cbx-1

Species

D. melanogaster

Name

FlyBase ID

FBal0045232

Feature type

allele

Associated gene

Dmel\Ubx

Associated Insertion(s)

Carried in Construct

Also Known As

Cbx¹Ubx¹

Key Links

Allele class

Mutagen

recombination

Nature of the Allele

Allele class

Mutagen

recombination

(Hendrickson and Sakonju, 1995)

Progenitor genotype

Ubx¹

(Hendrickson and Sakonju, 1995)

Ubx^Cbx-1

(Hendrickson and Sakonju, 1995)

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

homeotic

(Dutta and Li, 2017)

visible

(Dutta and Li, 2017)

visible | dominant

(Hartl et al., 2008, Hartl et al., 2008, Muller et al., 1999, Sipos et al., 1998, Hendrickson and Sakonju, 1995)

Phenotype Manifest In

alar lobe

(Muller et al., 1999)

wing

(Dutta and Li, 2017, Hartl et al., 2008, Hartl et al., 2008, Muller et al., 1999, Sipos et al., 1998, Hendrickson and Sakonju, 1995)

Detailed Description

Statement

Reference

Ubx^1:Cbx-1 adults exhibit partial wing-to-haltere transformation.

(Dutta and Li, 2017)

89.6% of heterozygotes show substantial loss of posterior wing tissue that often leads to the posterior region folding over the wing. 10.4% of heterozygotes have a large blister on the wing that comprises one third of the entire wing area or show wing necrosis.

(Hartl et al., 2008)

Heterozygotes have a wing with an abnormal shape and an alula that is greatly reduced in size.

(Muller et al., 1999)

z^a, Ubx^Cbx-1/+ flies do not differ from Ubx^Cbx-1/+, whereas the wings of z^a, Ubx^1:Cbx-1/+ are considerably less like halteres than those of Ubx^1:Cbx-1/+.

(Goldsborough and Kornberg, 1996)

The Cbx phenotype in Ubx^1:Cbx-1/In heterozygotes is enhanced by M(2)53¹.

(Golic and Golic, 1996)

Ubx^1:Cbx-1 heterozygotes show a dominant phenotype of warped and held-out wings because the Ubx^Cbx-1 part acts to misexpress Ubx⁺ on the homologue. This effect is disrupted by rearrangements that break once in between Ubx and the centromere and once elsewhere.

(Hendrickson and Sakonju, 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ubx^1:Cbx-1 has homeotic phenotype, enhanceable by Pc³

(Dutta and Li, 2017)

Ubx^1:Cbx-1 has visible phenotype, enhanceable by Pc³

(Dutta and Li, 2017)

Ubx^1:Cbx-1 has homeotic phenotype, enhanceable by tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Ubx^1:Cbx-1 has visible phenotype, enhanceable by tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Ubx^1:Cbx-1 has visible | dominant phenotype, enhanceable by Cap-H2^Z3-0019/Cap-H2[+]

(Hartl et al., 2008)

Ubx^1:Cbx-1 has visible | dominant phenotype, enhanceable by Cap-H2[+]/Cap-H2^TH1

(Hartl et al., 2008)

Ubx^1:Cbx-1 has visible | dominant phenotype, enhanceable by Df(3R)Exel6159/+

(Hartl et al., 2008)

Suppressed by

Statement

Reference

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by Scer\GAL4^sd-SG29.1/Cap-H2^UASp.mCherry

(Hartl et al., 2008, Hartl et al., 2008)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by Scer\GAL4^sd-SG29.1/Cap-H2^EY09979

(Hartl et al., 2008)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by T(2;3)60F;84B

(Muller et al., 1999)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by T(2;3)60F;85F

(Muller et al., 1999)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by In(3LR)61F;81EF

(Muller et al., 1999)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by In(3LR)80F;88C

(Muller et al., 1999)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by T(2;3)TSR-1^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by Ab(?;3)TSR-2^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by T(Y;3)TSR-11^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by T(2;3)TSR-3^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by In(3R)TSR-4^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by T(2;3)TSR-5^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by T(2;3)TSR-6^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by T(2;3)TSR-7^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by In(2R)TSR-8^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by T(2;3)TSR-9^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has visible | dominant phenotype, suppressible by In(3LR)TSR-10^Sz

(Sipos et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ubx^1:Cbx-1 has wing phenotype, enhanceable by tara⁰³⁸⁸¹

(Dutta and Li, 2017)

Ubx^1:Cbx-1 has wing phenotype, enhanceable by Pc³

(Dutta and Li, 2017)

Ubx^1:Cbx-1 has wing phenotype, enhanceable by Cap-H2^Z3-0019/Cap-H2[+]

(Hartl et al., 2008)

Ubx^1:Cbx-1 has wing phenotype, enhanceable by Cap-H2[+]/Cap-H2^TH1

(Hartl et al., 2008)

Ubx^1:Cbx-1 has wing phenotype, enhanceable by Df(3R)Exel6159/+

(Hartl et al., 2008)

Suppressed by

Statement

Reference

Ubx^1:Cbx-1 has wing blade posterior compartment phenotype, suppressible by MED19²/P{EPgy2}EY16159

(Boube et al., 2014)

Ubx^1:Cbx-1 has wing phenotype, suppressible by Scer\GAL4^sd-SG29.1/Cap-H2^UASp.mCherry

(Hartl et al., 2008, Hartl et al., 2008)

Ubx^1:Cbx-1 has wing phenotype, suppressible by Scer\GAL4^sd-SG29.1/Cap-H2^EY09979

(Hartl et al., 2008)

Ubx^1:Cbx-1 has wing phenotype, suppressible by T(2;3)TSR-1^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has wing phenotype, suppressible by Ab(?;3)TSR-2^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has wing phenotype, suppressible by T(2;3)TSR-3^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has wing phenotype, suppressible by In(3R)TSR-4^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has wing phenotype, suppressible by T(2;3)TSR-5^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has wing phenotype, suppressible by T(2;3)TSR-6^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has wing phenotype, suppressible by T(2;3)TSR-7^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has wing phenotype, suppressible by In(2R)TSR-8^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has wing phenotype, suppressible by T(2;3)TSR-9^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has wing phenotype, suppressible by In(3LR)TSR-10^Sz

(Sipos et al., 1998)

Ubx^1:Cbx-1 has wing phenotype, suppressible by T(Y;3)TSR-11^Sz

(Sipos et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The severity of the Ubx^1:Cbx-1/+ wing phenotype is dominantly enhanced by Cap-H2^Z3-0019, Cap-H2^TH1 and Df(3R)Exel6159; in each case the proportion of flies that show blistering or necrosis of the wing is increased.

Expression of Cap-H2^{Scer\UAS.P\T.T:Disc\RFP-mCherry} under the control of Scer\GAL4^sd-SG29.1 partially suppresses the Ubx^1:Cbx-1/+ wing phenotype.

Expression of Cap-H2^EY09979 under the control of Scer\GAL4^sd-SG29.1 partially suppresses the Ubx^1:Cbx-1/+ wing phenotype.

(Hartl et al., 2008)

Expression of Cap-H2^{Scer\UAS.P\T.T:Disc\RFP-mCherry} under the control of Scer\GAL4^sd-SG29.1 partially suppresses the wing phenotype of Ubx^1:Cbx-1/+ flies.

(Hartl et al., 2008)

The Ubx^1:Cbx-1 phenotype is suppressed by T(2;3)60F;84B, T(2;3)60F;85F, In(3LR)61F;81EF and In(3LR)80F;88C.

(Muller et al., 1999)

The wing phenotype of Ubx^1:Cbx-1 heterozygotes is significantly suppressed by T(2;3)TSR-1^Sz, Ab(?;3)TSR-2^Sz, T(2;3)TSR-3^Sz, In(3R)TSR-4^Sz, T(2;3)TSR-5^Sz, T(2;3)TSR-6^Sz, T(2;3)TSR-7^Sz, In(2R)TSR-8^Sz, T(2;3)TSR-9^Sz, In(3LR)TSR-10^Sz or T(Y;3)TSR-11^Sz.

(Sipos et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

The influence of various Ubx mutations in trans to Ubx^1:Cbx-1 on the synapsis-dependent phenotype of the Ubx^1:Cbx-1 chromosome has been studied.

(Babu et al., 1987)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Cbx

(Golic and Golic, 1996)

Cbx Ubx

(Duncan and Montgomery, 2002)

Cbx¹Ubx¹

(Muller et al., 1999, Sipos et al., 1998, Hendrickson and Sakonju, 1995, Babu et al., 1987)

Ubx

(Golic and Golic, 1996)

Ubx^1:Cbx-1

Ubx^Cbx-1Ubx¹

(Hartl et al., 2008, Hartl et al., 2008)

Ubx<up>cbx-1, Ubx1</up>

(Dutta and Li, 2017)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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