FlyBase Allele Report: Dmel\fax[M7]

General Information

Symbol

Dmel\fax^M7

Species

D. melanogaster

Name

FlyBase ID

FBal0045635

Feature type

allele

Associated gene

Dmel\fax

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

X ray

(Hill et al., 1995)

ethyl methanesulfonate

(Hill et al., 1995)

Progenitor genotype

Cytology

Description

Internal deletion, 5' breakpoint is 277 nucleotides within the first intron and the 3' breakpoint is 239 nucleotides in exon 2 at Leu335. The result is an inframe mRNA transcript encoding an internally deleted protein.

(Hill et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates chronic myeloid leukemia

modeled by Hsap\ABL1::Hsap\BCR^UAS.cBa

(Bernardoni et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous adults show no obvious mutant phenotype.

(Hill et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Abl⁴/Abl¹, fax^M7/fax[+] has lethal | prepupal stage phenotype, suppressible by ena[+]/ena^GC10

(Liebl et al., 2000)

Enhancer of

Statement

Reference

fax^M7/fax[+] is an enhancer of visible | adult stage phenotype of Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

fax^M7/fax[+] is an enhancer of lethal | prepupal stage phenotype of Abl⁴/Abl¹

(Liebl et al., 2000)

fax^M7/fax[+] is an enhancer of lethal phenotype of trio^M89/trio^S036810

(Liebl et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

fax^M7/fax[+] is an enhancer of eye phenotype of Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

fax^M7 is an enhancer of phenotype of Abl¹

(Hill et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

fax^M7 Abl¹/Df(3L)st-j7 individuals are lethal due to disruptions in the CNS longitudinal and commissural axons. One copy of Abl^+mTnabl-lys or Abl^+mTnabl moderately rescues the lethality. fax^M7 Abl¹/In(3L)std11 individuals are also lethal, one copy of Abl^+mTnabl rescues and Abl^+mTnabl-lys fails to rescue the lethality. The presence of Nrt^M2 does not affect lethality. fax^M7 Abl¹/Df(3L)st-g24 individuals are weakly viable, this semi-lethality can be alleviated by one copy of Abl^+mTnabl. Dosage sensitive interactions exist between fax^M7 and Nrt^M2. Abl^+mTnabl is unable to rescue the lethality of fax^- Nrt^- individuals.

(Hill et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8786

fax^M7

Notes on Origin

Discoverer

Comments

"X ray" was stated as tentative. "ethyl methanesulfonate" was stated as tentative. Haploinsufficiency dependent upon an Abl mutant background (HDA).

(Hill et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

fax^M7

(Bernardoni et al., 2019, Su et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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