FlyBase Allele Report: Dmel\trio[M89]

General Information

Symbol

Dmel\trio^M89

Species

D. melanogaster

Name

FlyBase ID

FBal0117288

Feature type

allele

Associated gene

Dmel\trio

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Nucleotide substitution: C?T. Amino acid replacement: L1412F.

(Liebl et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:1,024,942..1,024,942 [-]

Nucleotide change:

C1024942T

Reported nucleotide change:

C?T

Amino acid change:

L1412F | trio-PA; L1412F | trio-PC

Reported amino acid change:

L1412F

(Liebl et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with trio^IMP159.4)

(Forsthoefel et al., 2005)

lethal - all die before end of prepupal stage (with Df(3L)Fpa1)

(Liebl et al., 2000)

partially lethal - majority live (with trio^S036810)

(Dean et al., 2013)

some die during prepupal stage | recessive (with Df(3L)Fpa1)

(Liebl et al., 2000)

some die during P-stage (with trio^S036810)

(Dean et al., 2013)

viable (with trio^S036810)

(Liebl et al., 2000)

visible (with trio^S036810)

(Liebl et al., 2000)

Phenotype Manifest In

larval anterior commissure (with Df(3L)Fpa1)

(Liebl et al., 2000)

larval longitudinal connective (with Df(3L)Fpa1)

(Liebl et al., 2000)

larval posterior commissure (with Df(3L)Fpa1)

(Liebl et al., 2000)

symmetrical commissure (with trio^IMP159.4)

(Forsthoefel et al., 2005)

wing (with trio^S036810)

(Liebl et al., 2000)

Detailed Description

Statement

Reference

4.8% of segments have thin/missing commissures and 5.1% of segment have commissures with pathfinding errors in trio^IMP159.4/trio^M89 embryos.

(Forsthoefel et al., 2005)

Heterozygotes with Df(3L)Fpa1 show mild irregularities in the commissures and longitudinal connectives of the embryonic central nervous system. Heterozygotes of trio^S036810/trio^M89 show a wing blister phenotype but are otherwise wild type.

(Liebl et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

trio^M89/trio^S036810 has partially lethal - majority live phenotype, enhanceable by seq^9.17/seq[+]

(Dean et al., 2013)

trio^M89/trio^S036810 has some die during P-stage phenotype, enhanceable by seq^9.17/seq[+]

(Dean et al., 2013)

trio^M89/trio^S036810 has lethal phenotype, enhanceable by Abl¹/Abl[+]

(Liebl et al., 2000)

trio^M89/trio^S036810 has lethal phenotype, enhanceable by Abl⁴/Abl[+]

(Liebl et al., 2000)

trio^M89/trio^S036810 has lethal phenotype, enhanceable by fax^M7/fax[+]

(Liebl et al., 2000)

NOT Enhanced by

Statement

Reference

trio^M89/trio^S036810 has partially lethal - majority live phenotype, non-enhanceable by Df(2R)BSC273/+

(Dean et al., 2013)

trio^M89/trio^S036810 has some die during P-stage phenotype, non-enhanceable by Df(2R)BSC273/+

(Dean et al., 2013)

trio^M89/trio^S036810 has partially lethal - majority live phenotype, non-enhanceable by seq^vr5-5/seq[+]

(Dean et al., 2013)

trio^M89/trio^S036810 has some die during P-stage phenotype, non-enhanceable by seq^vr5-5/seq[+]

(Dean et al., 2013)

trio^M89/trio^S036810 has partially lethal - majority live phenotype, non-enhanceable by seq[+]/seq^vr5-48

(Dean et al., 2013)

trio^M89/trio^S036810 has some die during P-stage phenotype, non-enhanceable by seq[+]/seq^vr5-48

(Dean et al., 2013)

trio^M89/trio^IMP159.4 has abnormal neuroanatomy phenotype, non-enhanceable by fra⁴/fra[+]

(Forsthoefel et al., 2005)

Suppressed by

Statement

Reference

Abl⁴/Abl¹, Df(3L)Fpa1/trio^M89 has abnormal neuroanatomy phenotype, suppressible | partially by ena[+]/ena^GC10

(Forsthoefel et al., 2005)

Abl⁴/Abl¹, trio[+]/trio^M89 has lethal | prepupal stage phenotype, suppressible by ena[+]/ena^GC10

(Liebl et al., 2000)

Df(3L)Fpa1/trio^M89 has lethal phenotype, suppressible | partially by ena[+]/ena^GC10

(Liebl et al., 2000)

Enhancer of

Statement

Reference

trio[+]/trio^M89 is an enhancer of abnormal neuroanatomy phenotype of Df(2R)vg135/fra⁴

(Forsthoefel et al., 2005)

trio^M89/trio^IMP159.4 is an enhancer of abnormal neuroanatomy phenotype of fra⁴

(Forsthoefel et al., 2005)

trio[+]/trio^M89 is an enhancer of abnormal neuroanatomy phenotype of fra⁴

(Forsthoefel et al., 2005)

trio^M89/trio^S036810 is an enhancer of abnormal neuroanatomy phenotype of fra⁴

(Forsthoefel et al., 2005)

trio^M89/trio^IMP159.4 is an enhancer of abnormal neuroanatomy phenotype of Df(2R)vg135/fra⁴

(Forsthoefel et al., 2005)

trio[+]/trio^M89 is an enhancer of lethal | prepupal stage phenotype of Abl⁴/Abl¹

(Liebl et al., 2000)

Suppressor of

Statement

Reference

trio[+]/trio^M89 is a suppressor of decreased occurrence of cell division phenotype of CycE^JP

(Brumby et al., 2004)

Other

Statement

Reference

seq^9.17/seq[+], trio^M89/trio^S036810 has abnormal feeding behavior phenotype

(Dean et al., 2013)

Abl⁴/Abl¹, Df(3L)Fpa1/trio^M89 has abnormal neuroanatomy phenotype

(Forsthoefel et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

Df(3L)Fpa1/trio^M89 has larval anterior commissure phenotype, enhanceable by Abl¹/Abl[+]

(Liebl et al., 2000)

Df(3L)Fpa1/trio^M89 has larval longitudinal connective phenotype, enhanceable by Abl¹/Abl[+]

(Liebl et al., 2000)

Df(3L)Fpa1/trio^M89 has larval posterior commissure phenotype, enhanceable by Abl¹/Abl[+]

(Liebl et al., 2000)

trio^M89/trio^S036810 has larval longitudinal connective phenotype, enhanceable by Abl¹/Abl[+]

(Liebl et al., 2000)

NOT Enhanced by

Statement

Reference

trio^M89/trio^IMP159.4 has symmetrical commissure phenotype, non-enhanceable by fra⁴/fra[+]

(Forsthoefel et al., 2005)

Suppressed by

Statement

Reference

Abl⁴/Abl¹, Df(3L)Fpa1/trio^M89 has symmetrical commissure phenotype, suppressible | partially by ena[+]/ena^GC10

(Forsthoefel et al., 2005)

Enhancer of

Statement

Reference

trio[+]/trio^M89 is an enhancer of symmetrical commissure phenotype of Df(2R)vg135/fra⁴

(Forsthoefel et al., 2005)

trio^M89/trio^IMP159.4 is an enhancer of symmetrical commissure phenotype of fra⁴

(Forsthoefel et al., 2005)

trio[+]/trio^M89 is an enhancer of symmetrical commissure phenotype of fra⁴

(Forsthoefel et al., 2005)

trio^M89/trio^S036810 is an enhancer of symmetrical commissure phenotype of fra⁴

(Forsthoefel et al., 2005)

trio^M89/trio^IMP159.4 is an enhancer of symmetrical commissure phenotype of Df(2R)vg135/fra⁴

(Forsthoefel et al., 2005)

trio[+]/trio^M89 is an enhancer of larval anterior commissure phenotype of Abl⁴/Abl¹

(Liebl et al., 2000)

trio[+]/trio^M89 is an enhancer of larval longitudinal connective phenotype of Abl⁴/Abl¹

(Liebl et al., 2000)

trio[+]/trio^M89 is an enhancer of larval posterior commissure phenotype of Abl⁴/Abl¹

(Liebl et al., 2000)

NOT Enhancer of

Statement

Reference

trio^M89/trio^IMP159.4 is a non-enhancer of larval longitudinal connective phenotype of Df(2R)vg135/fra⁴

(Forsthoefel et al., 2005)

Suppressor of

Statement

Reference

trio[+]/trio^M89 is a suppressor of eye disc & S phase phenotype of CycE^JP

(Brumby et al., 2004)

trio[+]/trio^M89 is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

Other

Statement

Reference

Abl⁴/Abl¹, Df(3L)Fpa1/trio^M89 has symmetrical commissure phenotype

(Forsthoefel et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

seq^9.17 dominantly exacerbates the pre-pupal lethality of trio^M89/trio^S036810. However, survival to third instar larvae is indistinguishable between wild-type and the mutants. The seq^9.17/+; trio^M89/trio^S036810 larvae retain the forager-like feeding behaviour at a time (90-93 hours after hatching) when their siblings and all control larvae have already transitioned to wanderers.

(Dean et al., 2013)

Dominantly suppresses the S phase defects seen in the CycE^JP eye disc.

(Brumby et al., 2004)

The suppression of prepupal lethality of trio^M89/Df(3L)Fpa1 by ena^GC10 is incomplete. Lethality is delayed until pupariation, but adults are never recovered.

(Liebl et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

trio^S036810

(Liebl et al., 2000)

Rescued by

Df(3L)Fpa1/trio^M89 is rescued by trio^UAS.cLa/Scer\GAL4^sca-537.4

(Liebl et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

trio^M89

(Dean et al., 2013, Liebl et al., 2007)

trio^m89

(Kannan et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (7)

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