FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\polo16-1
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General Information
Symbol
Dmel\polo16-1
Species
D. melanogaster
Name
FlyBase ID
FBal0046071
Feature type
allele
Associated gene
Dmel\polo
Associated Insertion(s)
P{SUPor-P}polo16-1
Carried in Construct
Also Known As
l(3)77Aa16-1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Roseman et al., 1995)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}polo16-1
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{SUPor-P}
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygosity for polo16-1 does not result in increased levels of achiasmate X or 4th chromosome non-disjunction in In(1)FM7/X females (the In(1)FM7 chromosome is present to fully suppress X chromosomal exchange).

      (Xiang et al., 2007)

      polo1/polo16-1 females do not show gross defects in meiotic spindle formation.

      (Jang et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      polo16-1/polo[+] is an enhancer of abnormal mitotic cell cycle phenotype of sub131/sub1

      (Cesario et al., 2006)
      Suppressor of
      Statement
      Reference

      polo16-1/polo[+] is a suppressor of abnormal meiotic cell cycle | dominant phenotype of mtrm126

      (Xiang et al., 2007)
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      polo16-1/polo[+] is an enhancer of brain | larval stage phenotype of sub131/sub1

      (Cesario et al., 2006)
      Suppressor of
      Statement
      Reference

      polo16-1/polo[+] is a suppressor | partially of oocyte nucleus | oogenesis stage S12 phenotype of mtrm126

      (Xiang et al., 2007)

      polo16-1/polo[+] is a suppressor of karyosome phenotype of mtrm126

      (Xiang et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      poloKG03033/+ suppresses the elevated levels of achiasmate X and 4th chromosome nondisjunction seen in In(1)FM7/X mtrm126/+ females.

      The precocious nuclear envelope breakdown (NEB) seen in stage 12 oocytes of mtrm126/+ females is strongly suppressed by polo16-1/+. The defects in karyosome morphology seen in mtrm126/+ oocytes observed within 20 minutes of NEB are also largely suppressed by polo16-1/+.

      polo16-1/+ largely suppresses the karyosome maintenance defects seen in mtrm126/+ oocytes. polo16-1/+ fully suppresses the defect in X and 4th chromosome centromere co-orientation that is seen in mtrm126/+ females.

      (Xiang et al., 2007)

      sub1/sub131; polo16-1/+ rare survivors are sickly and small with abdominal patterning defects. Late larval developmental arrest is observed. Severe defects in spindle organization are observed, and spindles are unusually short. Larvae show a higher percentage of cells in mitosis compared to sub1/sub131 or polo16-1/+, and nearly four times that of wild-type.

      (Cesario et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      polo16-1/Df(3L)rdgC-co2 is partially rescued by polowt.GFP

      (Bonner et al., 2013)
      Not rescued by

      polo16-1/Df(3L)rdgC-co2 is not rescued by poloH518A.K520M.GFP

      (Bonner et al., 2013)
      Comments

      polowt.T:Avic\GFP rescues the lethality of polo16-1/Df(3L)rdgC-co2 animals, but rescued females are sterile.

      poloH518A.K520M.T:Avic\GFP fails to rescue the lethality of polo16-1/Df(3L)rdgC-co2 animals.

      (Bonner et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (11)