FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\shgE17B
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General Information
Symbol
Dmel\shgE17B
Species
D. melanogaster
Name
FlyBase ID
FBal0050497
Feature type
allele
Associated gene
Dmel\shg
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Uemura et al., 1996)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        shgE17B heterozygotes do not exhibit a visible phenotype nor a reduction in viability.

        (Tikhmyanova et al., 2010)

        Cell attachments in the tracheal branches of shg2/shgE17B mutant embryos are loosened and broken in several places, and adherens junctions appear diffuse and discontinuous. These phenotypes are more severe in the unicellular dorsal branch than the multicellular dorsal trunk.

        (Shindo et al., 2008)

        Mild embryonic tracheal phenotype.

        (Tanaka-Matakatsu et al., 1996)

        Mutants show disorganization of epithelial tissues in the head, ventral epidermis, Malpighian tubules and tracheal ducts. Malpighian tubule tip cells are present and differentiate into neurons, as in wild type. Tracheal tip cells are also present.

        (Uemura et al., 1996)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        shgE17B p130CAS1 double heterozygotes do not exhibit a visible phenotype nor a reduction in viability.

        shgE17B; p130CAS1 double homozygotes arrest in late embryogenesis (and thereby do not hatch). Athough most of the embryos form at least partial cuticles, absence of p130CAS1 significantly enhances shgE17B single mutant cuticle defects, with shgE17B; p130CAS1 mutant embryos showing severe defects that essentially eliminate head and ventral cuticle, while incomplete dorsal closure is reflected by the presence of holes in the dorsal cuticle.

        (Tikhmyanova et al., 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Df(2R)E2/shgE17B is rescued by shgUbi-p63E.sgGFP

        (Oda and Tsukita, 2001)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        l(2)E17B
        (Uemura et al., 1996)
        shgE17B
        (Araújo and Casanova, 2011, Tikhmyanova et al., 2010, Shindo et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)