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General Information
Symbol
Dmel\Diap18
Species
D. melanogaster
Name
FlyBase ID
FBal0050598
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    The ovarioles are poorly developed and atrophied in th8/th6B females.

    91% of th6B/th8 females fail to lay eggs. Females have severely stunted and irregularly shaped ovaries that appear atrophied. Most egg chambers exhibit overtly degenerative phenotypes.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressed by
    Statement
    Reference
    Phenotype Manifest In
    Suppressed by
    Statement
    Reference

    Diap16B/Diap18 has ovary phenotype, suppressible | partially by DarkCD4

    Enhancer of
    Statement
    Reference

    Diap18 is an enhancer of eye phenotype of hidGMR.PG/WGMR.PG

    Diap18 is an enhancer of eye phenotype of rprGMR.PH

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The NcI24/NcL32 combination partially suppresses the ovarian atrophy phenotype seen in th8/th6B mutants; the egg chamber is significantly enlarged compared to the th8/th6B mutant.

    The addition of ArkCD4/ArkCD4 or ArkCD4/+ to suppresses the sterility of th6B/th8 females, leading to 47% and 69% of females laying eggs respectively. Ovaries are considerably larger and generally wild-type in appearance. Most egg chambers are normal in morphology and number. Most egg chambers are normal in morphology and number.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Fails to complement
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (4)