FlyBase Allele Report: Dmel\wg[hs.2sev]

General Information

Symbol

Dmel\wg^hs.2sev

Species

D. melanogaster

Name

FlyBase ID

FBal0055789

Feature type

allele

Associated gene

Dmel\wg

Associated Insertion(s)

Carried in Construct

P{sev-wg.B}

Also Known As

sev-wg

Key Links

Transgenic product class

wild_type

(Brunner et al., 1997)

Mutagen

Nature of the Allele

Transgenic product class

wild_type

(Brunner et al., 1997)

Mutagen

FLPase

(Brunner et al., 1999)

in vitro construct

(Brunner et al., 1997)

Progenitor genotype

wg^FRT.hs.2sev

(Brunner et al., 1999)

Carried in construct

P{sev-wg.B}

Cytology

Description

Construct: Two copies of the sev enhancer drive wg expression.

(Brunner et al., 1997)

Allele components

Component

Use(s)

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | adult stage

(Reim et al., 2014)

visible

(Tran et al., 2008, Kramps et al., 2002, Brunner et al., 1997)

visible | adult stage

(Reim et al., 2014)

visible | dominant

(Brunner et al., 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

wg^hs.2sev eyes are rough.

(Port et al., 2011)

wg^hs.2sev animals have a rough eye.

(Song et al., 2010)

wg^hs.2sev flies have a rough eye phenotype.

(Tran et al., 2008)

Expression of one copy of the wg^hs.2sev transgene causes a rough eye phenotype.

(Banziger et al., 2006)

Mutants exhibit a rough eye phenotype.

(Kramps et al., 2002)

Flies carrying a single copy of wg^hs.2sev have smaller, narrower eyes than wild type. The regular hexagonal array of the ommatidia is disturbed and all interommatidial bristles are lost (sockets as well as bristles are missing). Ommatidia are also missing, mostly in anterior-dorsal regions of the eye. Misoriented ommatidia and ommatidia with missing photoreceptor cells are seen. There is an excess of pigment granules and there are up to four additional secondary pigment cells per ommatidium.

(Brunner et al., 1999)

Flies lack interommatidial bristles and have a dosage-sensitive rough eye phenotype.

(Brunner et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

wg^hs.2sev has visible | dominant phenotype, enhanceable by sv^spa-pol

(Brunner et al., 1999)

Suppressed by

Statement

Reference

wg^hs.2sev has visible | adult stage phenotype, suppressible | partially by lgs^17E.UAS/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has decreased size | adult stage phenotype, suppressible | partially by lgs^17E.UAS/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has visible | adult stage phenotype, suppressible | partially by amls^UAS.C-Tag:HA/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has visible | adult stage phenotype, suppressible | partially by amls^KK100852/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has visible | adult stage phenotype, suppressible | partially by amls^GD11667/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has visible | adult stage phenotype, suppressible | partially by amls^{RNAi.10xUAS.3-ORF}/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has decreased size | adult stage phenotype, suppressible | partially by amls^KK100852/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has decreased size | adult stage phenotype, suppressible | partially by amls^GD11667/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has decreased size | adult stage phenotype, suppressible | partially by amls^{RNAi.10xUAS.3-ORF}/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has decreased size | adult stage phenotype, suppressible | partially by amls^UAS.C-Tag:HA/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has visible phenotype, suppressible by trbd^Delta/trbd[+]

(Tran et al., 2008)

wg^hs.2sev has visible phenotype, suppressible by pan[+]/pan^unspecified

(Tran et al., 2008)

wg^hs.2sev has visible phenotype, suppressible by lgs^20F

(Kramps et al., 2002)

wg^hs.2sev has visible phenotype, suppressible by lgs^21L

(Kramps et al., 2002)

wg^hs.2sev has visible phenotype, suppressible by pygo¹³⁰

(Kramps et al., 2002)

wg^hs.2sev has visible phenotype, suppressible by lgs^17E

(Kramps et al., 2002)

wg^hs.2sev has visible | dominant phenotype, suppressible by sv^sev.PB

(Brunner et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

wg^hs.2sev has eye phenotype, enhanceable by Coop^R62/Coop^R56

(Song et al., 2010)

NOT Enhanced by

Statement

Reference

wg^hs.2sev has eye phenotype, non-enhanceable by Sps1^k11320

(Morey et al., 2001)

wg^hs.2sev has interommatidial bristle phenotype, non-enhanceable by Sps1^k11320

(Morey et al., 2001)

wg^hs.2sev has ommatidium phenotype, non-enhanceable by Sps1^k11320

(Morey et al., 2001)

Suppressed by

Statement

Reference

wg^hs.2sev has eye phenotype, suppressible | partially by lgs^17E.UAS/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has eye phenotype, suppressible | partially by amls^UAS.C-Tag:HA/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has eye phenotype, suppressible | partially by amls^KK100852/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has eye phenotype, suppressible | partially by amls^GD11667/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has eye phenotype, suppressible | partially by amls^{RNAi.10xUAS.3-ORF}/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Reim et al., 2014)

wg^hs.2sev has eye phenotype, suppressible by eca^KK109376/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Port et al., 2011)

wg^hs.2sev has eye phenotype, suppressible by Snx3^KK109353/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Port et al., 2011)

wg^hs.2sev has eye phenotype, suppressible by CHOp24^KK107384/Scer\GAL4^ey.PU/Scer\GAL4^GMR.PU

(Port et al., 2011)

wg^hs.2sev has eye phenotype, suppressible by trbd^Delta/trbd[+]

(Tran et al., 2008)

wg^hs.2sev has eye phenotype, suppressible by pan[+]/pan^unspecified

(Tran et al., 2008)

wg^hs.2sev has ommatidium phenotype, suppressible by wls¹/wls¹

(Banziger et al., 2006)

wg^hs.2sev has interommatidial bristle phenotype, suppressible by wls¹/wls¹

(Banziger et al., 2006)

wg^hs.2sev has eye phenotype, suppressible by wls¹/wls¹

(Banziger et al., 2006)

wg^hs.2sev has ommatidium phenotype, suppressible by wls²/wls²

(Banziger et al., 2006)

wg^hs.2sev has interommatidial bristle phenotype, suppressible by wls²/wls²

(Banziger et al., 2006)

wg^hs.2sev has eye phenotype, suppressible by wls²/wls²

(Banziger et al., 2006)

wg^hs.2sev has eye phenotype, suppressible by pygo¹³⁰

(Kramps et al., 2002)

wg^hs.2sev has ommatidium phenotype, suppressible by lgs^17E

(Kramps et al., 2002)

wg^hs.2sev has ommatidium phenotype, suppressible by lgs^20F

(Kramps et al., 2002)

wg^hs.2sev has ommatidium phenotype, suppressible by lgs^21L

(Kramps et al., 2002)

wg^hs.2sev has ommatidium phenotype, suppressible by pygo¹³⁰

(Kramps et al., 2002)

wg^hs.2sev has eye phenotype, suppressible by lgs^17E

(Kramps et al., 2002)

wg^hs.2sev has eye phenotype, suppressible by lgs^20F

(Kramps et al., 2002)

wg^hs.2sev has eye phenotype, suppressible by lgs^21L

(Kramps et al., 2002)

wg^hs.2sev has eye phenotype, suppressible by arm^S8

(Brunner et al., 1997)

wg^hs.2sev has eye phenotype, suppressible by arm^S9

(Brunner et al., 1997)

wg^hs.2sev has eye phenotype, suppressible by pan^S25

(Brunner et al., 1997)

wg^hs.2sev has eye phenotype, suppressible by pan^S28

(Brunner et al., 1997)

NOT suppressed by

Statement

Reference

wg^hs.2sev has interommatidial bristle phenotype, non-suppressible by Sps1^k11320

(Morey et al., 2001)

wg^hs.2sev has ommatidium phenotype, non-suppressible by Sps1^k11320

(Morey et al., 2001)

wg^hs.2sev has eye phenotype, non-suppressible by Sps1^k11320

(Morey et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

wg^hs.2sev rough eyes are suppressed when eca^KK109376 or Snx3^KK109353 or CHOp24^KK107384 is expressed using both Scer\GAL4^ey.PU and Scer\GAL4^GMR.PU.

(Port et al., 2011)

Heterozygosity for trbd^Delta or pan^unspecified suppresses the rough eye phenotype of wg^hs.2sev flies.

(Tran et al., 2008)

Mosaic animals in which most cells in the eye have a srt¹ or a srt² genotype show a significant reversion of the rough eye phenotype seen when following expression of the wg^hs.2sev transgene.

(Banziger et al., 2006)

The wg^hs.2sev phenotype is strongly enhanced by sv^spa-pol and suppressed by sv^sev.PB.

(Brunner et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

wg^hs.2sev

wg^sev.PB

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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