FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ciUAS.cHb
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General Information
Symbol
Dmel\ciUAS.cHb
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct b of Hepker
FlyBase ID
FBal0057692
Feature type
allele
Associated gene
Dmel\ci
Associated Insertion(s)
Carried in Construct
P{UAS-ci-cDNA}
Also Known As
UAS-ci
Key Links
Transgenic product class
cDNA
(Hepker et al., 1997)
wild_type
(Hepker et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Hepker et al., 1997)
wild_type
(Hepker et al., 1997)
Mutagen
in vitro construct
(Hepker et al., 1997)
Progenitor genotype
Carried in construct
P{UAS-ci-cDNA}
Cytology
Description

Expression of the ci coding region (made up of a 400bp DraI/EcoRI cDNA fragment which includes the 5' ci coding sequences and an EcoRI cDNA fragment containing the rest of the sequences) is governed by UASt regulatory sequences.

(Hepker et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ci
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ciScer\UAS.cHb under the control of Scer\GAL4ci.PC gives a variable phenotype depending on the insertion of the driver. The P{ci-GAL4.C}2 insertion produces a wild-type phenotype whereas the P{ci-GAL4.C}3 insertion sometimes produces a gain of function phenotype in which embryonic denticle belts are deleted and replaced with naked cuticle.

      (Croker et al., 2006)

      When driven by Scer\GAL4c591 ocelli increase in size and fuse. This phenotype is weaker than that seen when ciZn:C.Scer\UAS is expressed under the control of Scer\GAL4c591.

      (Amin et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4unspecified/ciUAS.cHb rescues ciCe-1

      (Hepker et al., 1997)
      Partially rescues

      Scer\GAL4ci.PC/ciUAS.cHb partially rescues ci94

      (Croker et al., 2006)
      Comments

      Expression of ciScer\UAS.cHb under the control of ciScer\UAS.cHb completely rescues the cuticle phenotype of ci94 embryos. Rescued embryos develop into adults that have normal morphology but are sterile.

      (Croker et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ciScer\UAS.cHb
      ciUAS.cHb
      Name Synonyms
      Saccharomyces cerevisiae UAS construct b of Hepker
      (Hepker et al., 1997)
      Secondary FlyBase IDs
        References (10)