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General Information
Symbol
Dmel\ciN:Zn.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0057694
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-ciR, UAS-CiN/Zn
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Deletion of C-terminal ci coding region beyond amino acid 684. Expression is governed by UASt regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of ciN:Zn.Scer\UAS under the control of Scer\GAL4neur-GAL4-A101 results in the loss of the ventral vdaB class IV neuron in 24% of stage 15 parasegments; however, the more lateral v'ada is never lost. Posterior derived MD neurons are also lost. For example, vbd is lost in 75% of parasegments. Examination of stage 12 embryos reveals that vdaB-loss is preceded by SOP1a loss in 22% of cases. SOP4a are not affected.

Expression of ciN:Zn.Scer\UAS under the control of Scer\GAL4ems.HRE impairs filzkorper formation but does not affect stigmatophore formation. However, expression of this transgene under the control of Scer\GAL4salm-459.2 has the reciprocal effect; stigmatophore formation is impaired while filzkorper formation is unaffected.

In ciN:Zn.Scer\UAS; Scer\GAL4btl.PS embryos, terminal tracheal branches are frequently duplicated. Time-lapse observation shows that the terminal branches initially develop normally, but that secondary terminal branches then form and migrate aberrantly anteriorly. About 1/3 of these duplicated branches arise from a single terminal cells.

Bolwig's organ formation is suppressed in embryos expressing ciN:Zn.Scer\UAS under the control of Scer\GAL4da.G32. Bolwig's organs are formed in embryos expressing ciN:Zn.Scer\UAS under the control of Scer\GAL4h-1J3.

Embryos expressing ciN:Zn.Scer\UAS under the control of Scer\GAL4en-e16E have an abnormal denticle pattern. In the middle of each belt, the denticle rows show a mirror-image 5, 4, 4, 5 pattern (numbers indicate the wild-type denticle row that the altered denticle rows resemble). This pattern is flanked by small denticles pointing away from the belt. The small anterior-pointing denticles at the anterior of each belt could either be type 1 or 6 by morphology.

When expression is driven by Scer\GAL4ptc-559.1 in the embryo, naked cuticle is deleted and the denticle belts are partially duplicated.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

The Bolwig's organ phenotype in embryos expressing ciN:Zn.Scer\UAS under the control of Scer\GAL4da.G32 is considerably rescued by co-expression of hhScer\UAS.cKa.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
ciN/Zn.Scer\UAS
ciN/Zn.UAS
ciN:Zn.Scer\UAS
ciN:Zn.UAS
Name Synonyms
Secondary FlyBase IDs
    References (8)